Brain-derived neurotrophic factor in Alzheimer's disease and its pharmaceutical potential
L Gao, Y Zhang, K Sterling, W Song - Translational neurodegeneration, 2022 - Springer
Synaptic abnormalities are a cardinal feature of Alzheimer's disease (AD) that are known to
arise as the disease progresses. A growing body of evidence suggests that pathological …
arise as the disease progresses. A growing body of evidence suggests that pathological …
Recent advances on the role of brain-derived neurotrophic factor (BDNF) in neurodegenerative diseases
Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are essential for neuronal
survival and growth. The signaling cascades initiated by BDNF and its receptor are the key …
survival and growth. The signaling cascades initiated by BDNF and its receptor are the key …
Female specific risk factors for the development of Alzheimer's disease neuropathology and cognitive impairment: Call for a precision medicine approach
C Udeh-Momoh, T Watermeyer - Ageing Research Reviews, 2021 - Elsevier
Alzheimer's disease (AD) includes a long asymptomatic stage, which precedes the formal
diagnosis of dementia. AD biomarker models provide a framework for precision medicine …
diagnosis of dementia. AD biomarker models provide a framework for precision medicine …
[HTML][HTML] Degradation of EEG microstates patterns in subjective cognitive decline and mild cognitive impairment: Early biomarkers along the Alzheimer's Disease …
Alzheimer's disease (AD) pathological changes may begin up to decades earlier than the
appearance of the first symptoms of cognitive decline. Subjective cognitive decline (SCD) …
appearance of the first symptoms of cognitive decline. Subjective cognitive decline (SCD) …
Brothers in arms: proBDNF/BDNF and sAPPα/Aβ-signaling and their common interplay with ADAM10, TrkB, p75NTR, sortilin, and sorLA in the progression of …
Brain-derived neurotrophic factor (BDNF) is an important modulator for a variety of functions
in the central nervous system (CNS). A wealth of evidence, such as reduced mRNA and …
in the central nervous system (CNS). A wealth of evidence, such as reduced mRNA and …
[HTML][HTML] Are TrkB receptor agonists the right tool to fulfill the promises for a therapeutic value of the brain-derived neurotrophic factor?
M Zagrebelsky, M Korte - Neural Regeneration Research, 2024 - journals.lww.com
Brain-derived neurotrophic factor signaling via its receptor tropomyosin receptor kinase B
regulates several crucial physiological processes. It has been shown to act in the brain …
regulates several crucial physiological processes. It has been shown to act in the brain …
PRedicting the EVolution of SubjectIvE Cognitive Decline to Alzheimer's Disease With machine learning: the PREVIEW study protocol
Background As disease-modifying therapies (DMTs) for Alzheimer's disease (AD) are
becoming a reality, there is an urgent need to select cost-effective tools that can accurately …
becoming a reality, there is an urgent need to select cost-effective tools that can accurately …
Ketone bodies mediate alterations in brain energy metabolism and biomarkers of Alzheimer's disease
Alzheimer's disease (AD) is the most common form of dementia. AD is a progressive
neurodegenerative disorder characterized by cognitive dysfunction, including learning and …
neurodegenerative disorder characterized by cognitive dysfunction, including learning and …
Association between BDNF Val66Met polymorphism and mild behavioral impairment in patients with Parkinson's disease
M Ramezani, JA Ruskey, K Martens, M Kibreab… - Frontiers in …, 2021 - frontiersin.org
Neuropsychiatric symptoms (NPS) are common in Parkinson's disease (PD) and have
demonstrated an association with the p. Val66Met, a polymorphism in the BDNF gene. Mild …
demonstrated an association with the p. Val66Met, a polymorphism in the BDNF gene. Mild …
An Interaction between Brain-Derived Neurotrophic Factor and Stress-Related Glucocorticoids in the Pathophysiology of Alzheimer's Disease
T Numakawa, R Kajihara - International Journal of Molecular Sciences, 2024 - mdpi.com
Both the brain-derived neurotrophic factor (BDNF) and glucocorticoids (GCs) play multiple
roles in various aspects of neurons, including cell survival and synaptic function. BDNF and …
roles in various aspects of neurons, including cell survival and synaptic function. BDNF and …