[HTML][HTML] Neutrophil extracellular traps and long COVID

A Shafqat, MH Omer, I Albalkhi… - Frontiers in …, 2023 - frontiersin.org
Post-acute COVID-19 sequelae, commonly known as long COVID, encompasses a range of
systemic symptoms experienced by a significant number of COVID-19 survivors. The …

Pharmacological targeting of senescence with senolytics as a new therapeutic strategy for neurodegeneration

M Richardson, DR Richardson - Molecular Pharmacology, 2024 - ASPET
Cellular senescence is a state of permanent cell-cycle arrest. Early in life, senescence has a
physiologic role in tumor suppression and wound healing. However, gradually, as these …

[HTML][HTML] The efferocytosis process in aging: Supporting evidence, mechanisms, and therapeutic prospects for age-related diseases

M Zhang, J Wei, Y Sun, C He, S Ma, X Pan… - Journal of Advanced …, 2024 - Elsevier
Background Aging is characterized by an ongoing struggle between the buildup of damage
caused by a combination of external and internal factors. Aging has different effects on …

[HTML][HTML] Alpha-synuclein pathology is associated with astrocyte senescence in a midbrain organoid model of familial Parkinson's disease

MN Muwanigwa, J Modamio-Chamarro… - Molecular and Cellular …, 2024 - Elsevier
Parkinson's disease (PD) is a complex, progressive neurodegenerative disease
characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta in …

Long COVID as a disease of accelerated biological aging: An opportunity to translate geroscience interventions

A Shafqat, MC Masters, U Tripathi, T Tchkonia… - Ageing Research …, 2024 - Elsevier
It has been four years since long COVID—the protracted consequences that survivors of
COVID-19 face—was first described. Yet, this entity continues to devastate the quality of life …

[HTML][HTML] Cellular senescence and kidney aging

N Rex, A Melk, R Schmitt - Clinical Science, 2023 - portlandpress.com
Life expectancy is increasing worldwide, and by 2050 the proportion of the world's
population over 65 years of age is estimated to surpass 1.5 billion. Kidney aging is …

[HTML][HTML] Peripheral vascular dysfunction and the aging brain

D Wahl, ZS Clayton - Aging (Albany NY), 2024 - ncbi.nlm.nih.gov
Aging is the greatest non-modifiable risk factor for most diseases, including cardiovascular
diseases (CVD), which remain the leading cause of mortality worldwide. Robust evidence …

[HTML][HTML] Human Brain In Vitro Model for Pathogen Infection-Related Neurodegeneration Study

Y Yan, AN Cho - International Journal of Molecular Sciences, 2024 - mdpi.com
Recent advancements in stem cell biology and tissue engineering have revolutionized the
field of neurodegeneration research by enabling the development of sophisticated in vitro …

Rejuvenating aged stem cells: therapeutic strategies to extend health and lifespan

F Matteini, S Montserrat‐Vazquez, MC Florian - FEBS letters, 2024 - Wiley Online Library
Aging is associated with a global decline in stem cell function. To date, several strategies
have been proposed to rejuvenate aged stem cells: most of these result in functional …

Inhibition of host N-myristoylation compromises the infectivity of SARS-CoV-2 due to Golgi-bypassing egress from lysosomes and endoplasmic reticulum

SH Saber, MR Shaker, J Sng, N Yak, SD Morrison… - bioRxiv, 2023 - biorxiv.org
Acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the
COVID-19 pandemic. Despite vaccinations, the development and use of neutralizing …