Intergenerational and transgenerational epigenetic inheritance in animals
Animals transmit not only DNA but also other molecules, such as RNA, proteins and
metabolites, to their progeny via gametes. It is currently unclear to what extent these …
metabolites, to their progeny via gametes. It is currently unclear to what extent these …
Epigenetic regulation of ageing: linking environmental inputs to genomic stability
Ageing is affected by both genetic and non-genetic factors. Here, we review the chromatin-
based epigenetic changes that occur during ageing, the role of chromatin modifiers in …
based epigenetic changes that occur during ageing, the role of chromatin modifiers in …
Methionine metabolism and methyltransferases in the regulation of aging and lifespan extension across species
AA Parkhitko, P Jouandin, SE Mohr, N Perrimon - Aging cell, 2019 - Wiley Online Library
Methionine restriction (MetR) extends lifespan across different species and exerts beneficial
effects on metabolic health and inflammatory responses. In contrast, certain cancer cells …
effects on metabolic health and inflammatory responses. In contrast, certain cancer cells …
A histone methylation network regulates transgenerational epigenetic memory in C. elegans
How epigenetic information is transmitted from generation to generation remains largely
unknown. Deletion of the C. elegans histone H3 lysine 4 dimethyl (H3K4me2) demethylase …
unknown. Deletion of the C. elegans histone H3 lysine 4 dimethyl (H3K4me2) demethylase …
Histone modifications as an intersection between diet and longevity
D Molina-Serrano, D Kyriakou, A Kirmizis - Frontiers in genetics, 2019 - frontiersin.org
Histone modifications are key epigenetic regulators that control chromatin structure and
gene transcription, thereby impacting on various important cellular phenotypes. Over the …
gene transcription, thereby impacting on various important cellular phenotypes. Over the …
Tri-methylation of histone H3 lysine 4 facilitates gene expression in ageing cells
C Cruz, M Della Rosa, C Krueger, Q Gao, D Horkai… - Elife, 2018 - elifesciences.org
Transcription of protein coding genes is accompanied by recruitment of COMPASS to
promoter-proximal chromatin, which methylates histone H3 lysine 4 (H3K4) to form …
promoter-proximal chromatin, which methylates histone H3 lysine 4 (H3K4) to form …
A histone demethylase links the loss of plasticity to nongenetic inheritance and morphological change
NA Levis, EJ Ragsdale - Nature Communications, 2023 - nature.com
Plasticity is a widespread feature of development, enabling phenotypic change based on the
environment. Although the evolutionary loss of plasticity has been linked both theoretically …
environment. Although the evolutionary loss of plasticity has been linked both theoretically …
Genome‐wide association and environmental suppression of the mortal germline phenotype of wild C. elegans
The animal germline lineage needs to be maintained along generations. However, some
Caenorhabditis elegans wild isolates display a mortal germline phenotype, leading to …
Caenorhabditis elegans wild isolates display a mortal germline phenotype, leading to …
The KDM5 family of histone demethylases as targets in oncology drug discovery
PB Rasmussen, P Staller - Epigenomics, 2014 - Taylor & Francis
There is growing evidence for a causal role of the KDM5 family of histone demethylases in
human cancer. In particular, KDM5A (JARID1A/RBP2) and KDM5B (JARID1B/PLU1) …
human cancer. In particular, KDM5A (JARID1A/RBP2) and KDM5B (JARID1B/PLU1) …
Non-genomic transmission of longevity between generations: potential mechanisms and evidence across species
Accumulating animal and human data indicate that environmental exposures experienced
during sensitive developmental periods may strongly influence risk of adult disease …
during sensitive developmental periods may strongly influence risk of adult disease …