BDNF as a promising therapeutic agent in Parkinson's disease

E Palasz, A Wysocka, A Gasiorowska… - International journal of …, 2020 - mdpi.com
Brain-derived neurotrophic factor (BDNF) promotes neuroprotection and neuroregeneration.
In animal models of Parkinson's disease (PD), BDNF enhances the survival of dopaminergic …

Brain-derived neurotrophic factor in brain disorders: focus on neuroinflammation

B Lima Giacobbo, J Doorduin, HC Klein… - Molecular …, 2019 - Springer
Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in the
healthy and diseased brain. As a result, there is a large body of evidence that associates …

Decreased serum brain-derived neurotrophic factor (BDNF) levels in patients with Alzheimer's disease (AD): a systematic review and meta-analysis

TKS Ng, CSH Ho, WWS Tam, EH Kua… - International journal of …, 2019 - mdpi.com
Findings from previous studies reporting the levels of serum brain-derived neurotrophic
factor (BDNF) in patients with Alzheimer's disease (AD) and individuals with mild cognitive …

Actions of brain-derived neurotrophin factor in the neurogenesis and neuronal function, and its involvement in the pathophysiology of brain diseases

T Numakawa, H Odaka, N Adachi - International journal of molecular …, 2018 - mdpi.com
It is well known that brain-derived neurotrophic factor, BDNF, has an important role in a
variety of neuronal aspects, such as differentiation, maturation, and synaptic function in the …

[HTML][HTML] The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease

J Budni, T Bellettini-Santos, F Mina, ML Garcez… - Aging and …, 2015 - ncbi.nlm.nih.gov
Aging is a normal physiological process accompanied by cognitive decline. This aging
process has been the primary risk factor for development of aging-related diseases such as …

[HTML][HTML] Neuroprotection against oxidative stress: Phytochemicals targeting TrkB signaling and the Nrf2-ARE antioxidant system

MA Hannan, R Dash, AAM Sohag… - Frontiers in Molecular …, 2020 - frontiersin.org
Oxidative stress (OS) plays a critical role in the pathophysiology of several brain-related
disorders, including neurodegenerative diseases and ischemic stroke, which are the major …

The relation of the brain-derived neurotrophic factor with microRNAs in neurodegenerative diseases and ischemic stroke

C Eyileten, L Sharif, Z Wicik, D Jakubik… - Molecular …, 2021 - Springer
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth
factors that plays a crucial role in the development of the nervous system while supporting …

[HTML][HTML] Alpha-synuclein as a biomarker of Parkinson's disease: good, but not good enough

U Ganguly, S Singh, S Pal, S Prasad… - Frontiers in aging …, 2021 - frontiersin.org
Parkinson's disease (PD) is the second most common neurodegenerative disorder of the
elderly, presenting primarily with symptoms of motor impairment. The disease is diagnosed …

Unfolding the Role of BDNF as a Biomarker for Treatment of Depression

T Rana, T Behl, A Sehgal, P Srivastava… - Journal of Molecular …, 2021 - Springer
Depression is a well-known disabling mental illness characterized by sadness, loss of
interest in activities, and decreased energy. The symptoms of depression are usually …

Probiotic modulation of the microbiota-gut-brain axis and behaviour in zebrafish

L Borrelli, S Aceto, C Agnisola, S De Paolo… - Scientific reports, 2016 - nature.com
The gut microbiota plays a crucial role in the bi-directional gut–brain axis, a communication
that integrates the gut and central nervous system (CNS) activities. Animal studies reveal …