It is now nearly 5 years since the last of the currently recognised 5-HT receptors was
identified in terms of its cDNA sequence. Over this period, much effort has been directed …

The existence of an endogenous vasoconstrictor in blood serum (Stevens and Lee, 1984;
Brodie, 1900) and the presence in the gut of a substance that increases intestinal motility …

Several areas in the brainstem and forebrain are important for the modulation and
expression of the sleep/wake cycle. Even if the first observations of biochemical events in …

WAY-100635 (N-[2-[4-(2-methoxyphenyl)-1-piperazinyl] ethyl]-N-(2-pyridinyl)
cyclohexanecarboxamide trihydrochloride) is an achiral phenylpiperazine derivative that …

Although considerable progress has been made in characterising the 5-HT1A receptor
using agonists, partial agonists or non-selective antagonists, further studies of 5-HT1A …

1 The acute inhibitory effect of selective 5‐hydroxytryptamine (serotonin) reuptake inhibitors
(SSRIs) on 5‐HT neuronal activity may offset their ability to increase synaptic 5‐HT in the …

The tritiated derivative of the novel silent 5-HT1A receptor antagonist WAY 100635 [N-(2-(4-
(2-methoxyphenyl)-1-pineperazinyl) ethyl)-N-(2-pridinyl) cyclohexane carboxamide] was …

Serotonin (5-HT) 5-HT1A autoreceptors (5-HT1AautoR) and the plasmalemmal 5-HT
transporter (SERT) are key elements in the regulation of central 5-HT function and its …

The purpose of this study was to develop a radiopharmaceutical that could be used to
selectively image 5‐HT1A receptors with positron emission tomography (PET) No‐carrier …

In the rat brain, the dorsal raphe nucleus contains a large proportion of serotoninergic
neurons, which are mostly regulated by somato-dendritic 5-HT1A autoreceptors. This …