Recent advances in understanding different RNAs and unique features of their biology have
revealed a wealth of information. However, approaches to identify small molecules that …

The past decade has seen an explosion of interest in long noncoding RNAs (lncRNAs).
However, despite the massive volume of scientific data implicating these transcripts in a …

In many virus families, tens to thousands of proteins assemble spontaneously into a capsid
(protein shell) while packaging the genomic nucleic acid. This review summarizes recent …

The Watson-Crick base paring properties of DNA and RNA have led to their development as
excellent building blocks for the construction of nanomaterials by bottom up selfassembly [1 …

Conspectus Viruses are unique among living organisms insofar as they can be reconstituted
“from scratch”, that is, synthesized from purified components. In the simplest cases, their …

Structural DNA nanotechnology is beginning to emerge as a widely accessible research tool
to mechanistically study diverse biophysical processes. Enabled by scaffolded DNA origami …

RNA viruses encode the information required to usurp cellular metabolism and gene
regulation and to enable their own replication in two ways: in the linear sequence of their …

Following the discovery of numerous long non-coding RNA (lncRNA) transcripts in the
human genome, their important roles in biology and human disease are emerging. Recent …

Long RNA molecules are at the core of gene regulation across all kingdoms of life, while
also serving as genomes in RNA viruses. Few studies have addressed the basic physical …

Ribonucleoprotein complexes (RNPs) are central to all processes in the cell. One of the
prerequisites to understand how RNPs work is to determine their high-resolution structures …