Sphingolipids as functional food components: Benefits in skin improvement and disease prevention

T Sugawara - Journal of Agricultural and Food Chemistry, 2022 - ACS Publications
Sphingolipids are ubiquitous components in eukaryotic organisms and have attracted
attention as physiologically functional lipids. Sphingolipids with diverse structures are …

Mammalian sphingoid bases: Biophysical, physiological and pathological properties

AC Carreira, TC Santos, MA Lone, E Zupančič… - Progress in lipid …, 2019 - Elsevier
Sphingoid bases encompass a group of long chain amino alcohols which form the essential
structure of sphingolipids. Over the last years, these amphiphilic molecules were moving …

[HTML][HTML] Large-scale lipidomics identifies associations between plasma sphingolipids and T2DM incidence

WS Chew, F Torta, S Ji, H Choi, H Begum, X Sim… - JCI insight, 2019 - ncbi.nlm.nih.gov
BACKGROUND Sphingolipids (SPs) are ubiquitous, structurally diverse molecules that
include ceramides, sphingomyelins (SMs), and sphingosines. They are involved in various …

Subunit composition of the mammalian serine-palmitoyltransferase defines the spectrum of straight and methyl-branched long-chain bases

MA Lone, AJ Hülsmeier, EM Saied… - Proceedings of the …, 2020 - National Acad Sciences
Sphingolipids (SLs) are chemically diverse lipids that have important structural and
signaling functions within mammalian cells. SLs are commonly defined by the presence of a …

[HTML][HTML] Dietary sphinganine is selectively assimilated by members of the mammalian gut microbiome

MT Lee, HH Le, EL Johnson - Journal of lipid research, 2021 - ASBMB
Functions of the gut microbiome have a growing number of implications for host metabolic
health, with diet being one of the most significant influences on microbiome composition …

[HTML][HTML] Diverse biological functions of sphingolipids in the CNS: ceramide and sphingosine regulate myelination in developing brain but stimulate demyelination …

S Dasgupta, SK Ray - Journal of neurology and psychology, 2017 - ncbi.nlm.nih.gov
Sphingolipids are enriched in the Central Nervous System (CNS) and display multiple
biological functions. They participate in tissue development, cell recognition and adhesion …

Sphingolipids in food and their critical roles in human health

X Wang, Y Wang, J Xu, C Xue - Critical Reviews in Food Science …, 2021 - Taylor & Francis
Sphingolipids (SLs) are ubiquitous structural components of cell membranes and are
essential for cell functions under physiological conditions or during disease progression …

[HTML][HTML] Immunomodulatory sphingosine-1-phosphates as plasma biomarkers of Alzheimer's disease and vascular cognitive impairment

XY Chua, YL Chai, WS Chew, JR Chong… - Alzheimer's Research & …, 2020 - Springer
Background There has been ongoing research impetus to uncover novel blood-based
diagnostic and prognostic biomarkers for Alzheimer's disease (AD), vascular dementia …

Sphingosine 1–phosphate signaling induces SNAI2 expression to promote cell invasion in breast cancer cells

W Wang, T Hind, BWS Lam, DR Herr - The FASEB Journal, 2019 - Wiley Online Library
Epithelial‐mesenchymal transition (EMT) is a critical process implicated in the initial stage of
cancer metastasis, which is the major cause of tumor recurrence and mortality. Although key …

'Crystal'clear? Lysophospholipid receptor structure insights and controversies

VA Blaho, J Chun - Trends in pharmacological sciences, 2018 - cell.com
Lysophospholipids (LPLs), particularly sphingosine 1-phosphate (S1P) and
lysophosphatidic acid (LPA), are bioactive lipid modulators of cellular homeostasis and …