Background Empirical, updated country-level estimates on the proportion of cirrhosis
attributable to viral hepatitis are required. We estimated the prevalence of hepatitis B virus …

As the essential regulators of organ fibrosis, macrophages undergo marked phenotypic and
functional changes after organ injury. These changes of macrophage phenotype and …

The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates
innate immune responses by activating caspase-1 and the inflammatory cytokines …

Background: Patients with cirrhosis and hepatocellular carcinoma (HCC) require extensive
care. Personalized education can improve their outcomes. ChatGPT (Generative Pre-trained …

The liver is an organ that is particularly exposed to reactive oxygen species (ROS), which
not only arise during metabolic functions but also during the biotransformation of …

Adult hepatocyte identity is constructed throughout embryonic development and fine-tuned
after birth. A multinodular network of transcription factors, along with pre-mRNA splicing …

Background Liver cirrhosis is a major cause of death worldwide. Cirrhosis develops after a
long asymptomatic period of fibrosis progression, with the diagnosis frequently occurring …

Cirrhosis is an important cause of morbidity and mortality in people with chronic liver
disease worldwide. In 2019, cirrhosis was associated with 2.4% of global deaths. Owing to …

Cirrhosis causes a heavy global burden. In this review, we summarized up-to-date
epidemiological features of cirrhosis and its complications. Recent epidemiological studies …

Liver cirrhosis is the end stage of chronic liver diseases without approved clinical drugs. In
this study, a new strategy that uses a C–C chemokine receptor 2 (CCR2) small interfering …