How vascular smooth muscle cell phenotype switching contributes to vascular disease

G Cao, X Xuan, J Hu, R Zhang, H Jin… - Cell Communication and …, 2022 - Springer
Vascular smooth muscle cells (VSMCs) are the most abundant cell in vessels. Earlier
experiments have found that VSMCs possess high plasticity. Vascular injury stimulates …

Epidemiology and management of aortic disease: aortic aneurysms and acute aortic syndromes

E Bossone, KA Eagle - Nature Reviews Cardiology, 2021 - nature.com
The aorta is the 'greatest artery', through which oxygenated blood is delivered from the left
ventricle to end organs with each cardiac cycle (200 million litres of blood transported in an …

Gut microbiome dysbiosis contributes to abdominal aortic aneurysm by promoting neutrophil extracellular trap formation

Z Tian, Y Zhang, Z Zheng, M Zhang, T Zhang, J Jin… - Cell host & …, 2022 - cell.com
Abdominal aortic aneurysm (AAA) is an insidious and lethal vascular disease that lacks
effective nonsurgical interventions. Gut microbiota dysbiosis plays key roles in many …

Self-healing polyurethane-elastomer with mechanical tunability for multiple biomedical applications in vivo

C Jiang, L Zhang, Q Yang, S Huang, H Shi… - Nature …, 2021 - nature.com
The unique properties of self-healing materials hold great potential in the field of biomedical
engineering. Although previous studies have focused on the design and synthesis of self …

[HTML][HTML] Cellular senescence in cardiovascular diseases: a systematic review

C Hu, X Zhang, T Teng, ZG Ma, QZ Tang - Aging and disease, 2022 - ncbi.nlm.nih.gov
Aging is a prominent risk factor for cardiovascular diseases, which is the leading cause of
death around the world. Recently, cellular senescence has received potential attention as a …

Vascular smooth muscle cells in aortic aneurysm: from genetics to mechanisms

H Lu, W Du, L Ren, MH Hamblin… - Journal of the …, 2021 - Am Heart Assoc
Aortic aneurysm, including thoracic aortic aneurysm and abdominal aortic aneurysm, is the
second most prevalent aortic disease following atherosclerosis, representing the ninth …

Extracellular matrix, regional heterogeneity of the aorta, and aortic aneurysm

S Jana, M Hu, M Shen, Z Kassiri - Experimental & molecular medicine, 2019 - nature.com
Aortic aneurysm is an asymptomatic disease with dire outcomes if undiagnosed. Aortic
aneurysm rupture is a significant cause of death worldwide. To date, surgical repair or …

AGGF1 therapy inhibits thoracic aortic aneurysms by enhancing integrin α7-mediated inhibition of TGF-β1 maturation and ERK1/2 signaling

X Da, Z Li, X Huang, Z He, Y Yu, T Tian, C Xu… - Nature …, 2023 - nature.com
Thoracic aortic aneurysm (TAA) is a localized or diffuse dilatation of the thoracic aortas, and
causes many sudden deaths each year worldwide. However, there is no effective …

AAA revisited: a comprehensive review of risk factors, management, and hallmarks of pathogenesis

V Kessler, J Klopf, W Eilenberg, C Neumayer… - Biomedicines, 2022 - mdpi.com
Despite declining incidence and mortality rates in many countries, the abdominal aortic
aneurysm (AAA) continues to represent a life-threatening cardiovascular condition with an …

[HTML][HTML] Immune and inflammatory mechanisms of abdominal aortic aneurysm

AC Márquez-Sánchez, EK Koltsova - Frontiers in immunology, 2022 - frontiersin.org
Abdominal aortic aneurysm (AAA) is a life-threatening cardiovascular disease. Immune-
mediated infiltration and a destruction of the aortic wall during AAA development plays …