The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

There has been increasing interest in complex coacervates for deriving and transporting
biomaterials. Complex coacervates are a dense, polyelectrolyte‐rich liquid that results from …

Complex coacervates can form through the electrostatic complexation of oppositely charged
polymers. The material properties of the resulting coacervates can change based on the …

Micelleplexes show great promise as effective polymeric delivery systems for nucleic acids.
Although studies have shown that spherical micelleplexes can exhibit superior cellular …

Nucleic acid (NA) therapeutics are a rapidly growing class of biomedicines with the ability to
manipulate gene expression in potent and specific manner, and with the enormous potential …

Rheology is a powerful method for material characterization that can provide detailed
information about the self-assembly, structure, and intermolecular interactions present in a …

Protein-containing polyelectrolyte complexes (PECs) are a diverse class of materials,
composed of two or more oppositely charged polyelectrolytes that condense and phase …

Gene editing with CRISPR/Cas9 is revolutionizing biotechnology and medical research, yet
affordable, efficient, and tailorable delivery systems are urgently needed to advance …

Herein, we examine the complexation and biological delivery of a short single-stranded
antisense oligonucleotide (ASO) payload with four polymer derivatives that form two …

Polyelectrolyte complexation has been conventionally focused on the thermodynamic states,
where assemblies have equilibrated in solutions. Far less attention has been given to …