Benzimidazole, a fused heterocycle bearing benzene and imidazole has gained
considerable attention in the field of contemporary medicinal chemistry. The moiety is of …

The increasing incidence of microbial resistance and newly emerging pathogens have
become a serious challenge for public health. More and more efforts have been directed to …

A series of novel aminopyrimidinyl benzimidazoles as potentially antimicrobial agents were
designed, synthesized and characterized by IR, NMR and HRMS spectra. The biological …

DNA topoisomerases constitute a large family of enzymes that are essential for all domains
of life. Although they share general reaction chemistry and the capacity to govern DNA …

Metal-based drugs, including lanthanide complexes, have been extremely effective in
clinical treatments against various diseases and have raised major interest in recent …

Clinically significant antibiotic resistance is one of the greatest challenges of the twenty‐first
century. However, new antibacterial agents are currently being developed at a much slower …

The rise and emergence of resistance to antifungal drugs by diverse pathogenic fungal
strains have resulted in an increase in demand for new antifungal agents. Various …

Highlights•DNA topoisomerases are key targets for antibacterial and anticancer
chemotherapy.•TB topo I is validated as an antibacterial target.•Inhibitors that target TB topo I …

Abstract The benzimidazole derivative (E)-2-((4-(1H-benzo [d] imidazol-2-yl) phenylimino)
methyl)-4-bromo phenol and the corresponding Zn (II), Ni (II), Cu (II), and Pd (II) complexes …

A series of novel benzimidazole quinolones as potential antimicrobial agents were designed
and synthesized. Most of the prepared compounds exhibited good or even stronger …