Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases
worldwide and is often associated with aspects of metabolic syndrome. Despite its …

The correct identification of patients at increased risk of non-alcoholic steatohepatitis
(NASH) and advanced fibrosis is a critical step in the assessment of non-alcoholic fatty liver …

Background & Aims Increased de novo lipogenesis creates excess intrahepatic fat and
lipotoxins, propagating liver damage in nonalcoholic steatohepatitis. TVB-2640, a fatty acid …

Nonalcoholic fatty liver disease (NAFLD) is a spectrum comprised of isolated steatosis,
nonalcoholic steatohepatitis (NASH), advanced fibrosis, and cirrhosis. The majority of …

Ether lipids, such as plasmalogens, are peroxisome-derived glycerophospholipids in which
the hydrocarbon chain at the sn-1 position of the glycerol backbone is attached by an ether …

The diagnostic assessment of liver injury is an important step in the management of patients
with chronic liver disease (CLD). Although liver biopsy is the reference standard for the …

Angiopoietin-like protein (ANGPTL) 3 regulates plasma lipids by inhibiting LPL and
endothelial lipase (EL). ANGPTL3 inactivation lowers LDL-C independently of the classical …

Although Schwann cell myelin breakdown is the universal outcome of a remarkably wide
range of conditions that cause disease or injury to peripheral nerves, the cellular and …

Background & Aims Nonalcoholic fatty liver disease (NAFLD) is a consequence of defects in
diverse metabolic pathways that involve hepatic accumulation of triglycerides. Features of …

The endolysosomal system is critical for the maintenance of cellular homeostasis. However,
how endolysosomal compartment is regulated by mitochondrial function is largely unknown …