Rapid Formation of Intramolecular Disulfide Bridges using Light: An Efficient Method to Control the Conformation and Function of Bioactive Peptides
F He, Y Chai, Z Zeng, F Lu, H Chen, J Zhu… - Journal of the …, 2023 - ACS Publications
Disulfide bonds are widely found in natural peptides and play a pivotal role in stabilizing
their secondary structures, which are highly associated with their biological functions …
their secondary structures, which are highly associated with their biological functions …
Protein-Based Tools for Studying Neuromodulation
W Wang - ACS Chemical Biology, 2024 - ACS Publications
Neuromodulators play crucial roles in regulating neuronal activity and affecting various
aspects of brain functions, including learning, memory, cognitive functions, emotional states …
aspects of brain functions, including learning, memory, cognitive functions, emotional states …
Chemogenetic Tools in Focus: Proximity, Conformation, and Sterics
Chemogenetic tools are genetically encoded systems regulated by user‐defined chemicals.
Their ability to temporally modulate protein functions in specific cell populations has …
Their ability to temporally modulate protein functions in specific cell populations has …
Single-chain fluorescent integrators for mapping G-protein-coupled receptor agonists
G protein-coupled receptors (GPCRs) transduce the effects of many neuromodulators
including dopamine, serotonin, epinephrine, acetylcholine, and opioids. The localization of …
including dopamine, serotonin, epinephrine, acetylcholine, and opioids. The localization of …
Designing Chemical-and Light-Activated Protein Switches for Regulating Peptide Functions
J Shen - 2023 - deepblue.lib.umich.edu
Peptides serve important biological functions including neuromodulation, hormonal
regulation, cell signaling, protein localization, and enzyme inhibition. The ability to modulate …
regulation, cell signaling, protein localization, and enzyme inhibition. The ability to modulate …