Increasing evidence indicates the involvement of B cells in the pathogenesis of multiple
sclerosis (MS), but their precise roles are unclear. In this Review, we provide an overview of …

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system (CNS) where immunopathology is thought to be mediated by myelin-reactive CD4+ T …

Multiple sclerosis is an autoimmune disease that is caused by the interplay of genetic,
particularly the HLA-DR15 haplotype, and environmental risk factors. How these etiologic …

Importance Hematopoietic stem cell transplantation (HSCT) represents a potentially useful
approach to slow or prevent progressive disability in relapsing-remitting multiple sclerosis …

These updated EBMT guidelines review the clinical evidence, registry activity and
mechanisms of action of haematopoietic stem cell transplantation (HSCT) in multiple …

Naive T cells have long been regarded as a developmentally synchronized and fairly
homogeneous and quiescent cell population, the size of which depends on age, thymic …

Autologous haematopoietic stem cell transplantation (AHSCT) is a multistep procedure that
enables destruction of the immune system and its reconstitution from haematopoietic stem …

Experimental autoimmune encephalomyelitis (EAE) is the most commonly used
experimental model for the human inflammatory demyelinating disease, multiple sclerosis …

Importance Autologous hematopoietic stem cell transplantation (AHSCT) may be effective in
aggressive forms of multiple sclerosis (MS) that fail to respond to standard therapies …

Hematopoietic stem cell transplantation (HSCT) has evolved for> 20 years as a specific
treatment of patients with autoimmune disease (AD). Using European Society for Blood and …