Clinical research challenges posed by difficult-to-treat depression

AJ Rush, HA Sackeim, CR Conway… - Psychological …, 2022 - cambridge.org
Approximately one-third of individuals in a major depressive episode will not achieve
sustained remission despite multiple, well-delivered treatments. These patients experience …

Stress gets into the belly: Early life stress and the gut microbiome

L Hantsoo, BS Zemel - Behavioural brain research, 2021 - Elsevier
Research has established that stress “gets under the skin,” impacting neuroendocrine and
neuroimmune pathways to influence risk for physical and mental health outcomes. These …

Risk factors of chronic course of anxiety and depressive disorders: a 3-year longitudinal study in the general population

KCP Remmerswaal, M Ten Have, R de Graaf… - Social psychiatry and …, 2023 - Springer
Background Risk factors of a chronic course of anxiety and depressive disorders were
previously studied using a limited definition of recovery, ie remission of the index disorder …

[PDF][PDF] The Feasibility and Acceptability of Using Smartphones and Wearable Devices to Identify Digital Biomarkers of Depression in Psychological Therapies

V de Angel Echeverry - 2023 - kclpure.kcl.ac.uk
Background Remote Measurement Technologies (RMTs), such as smartphones and
wearable devices, could improve psychological treatment outcomes in depression through …