Recent progress in continuous manufacturing of oral solid dosage forms

V Vanhoorne, C Vervaet - International Journal of Pharmaceutics, 2020 - Elsevier
Continuous drug product manufacturing is slowly being implemented in the pharmaceutical
industry. Although the benefits related to the quality and cost of continuous manufacturing …

Using residence time distribution in pharmaceutical solid dose manufacturing–A critical review

P Bhalode, H Tian, S Gupta, SM Razavi… - International journal of …, 2021 - Elsevier
While continuous manufacturing (CM) of pharmaceutical solid-based drug products has
been shown to be advantageous for improving the product quality and process efficiency in …

A multivariate formulation and process development platform for direct compression

J Dhondt, J Bertels, A Kumar… - International Journal of …, 2022 - Elsevier
The efficient development of robust tableting processes is challenging due to the lack of
mechanistic understanding on the impact of raw material properties and process parameters …

Morphological distribution mapping: Utilisation of modelling to integrate particle size and shape distributions

JF Gamble, I Akseli, AP Ferreira, M Leane… - International Journal of …, 2023 - Elsevier
The aim of this work was to develop approaches to utilize whole particle distributions for
both particle size and particle shape parameters to map the full range of particle properties …

Selection of an appropriate tracer to measure the residence time distribution (RTD) of continuous powder blending operations

SM Razavi, AD Román-Ospino, P Bhalode… - Powder Technology, 2023 - Elsevier
Residence time distributions (RTDs) are quickly becoming an important component of the
quality control strategy for continuous manufacturing (CM) of pharmaceutical products …

A multivariate approach to predict the volumetric and gravimetric feeding behavior of a low feed rate feeder based on raw material properties

N Bostijn, J Dhondt, A Ryckaert, E Szabó… - International journal of …, 2019 - Elsevier
In this study, the volumetric and gravimetric feeding behavior of 15 pharmaceutical powders
on a low feed rate feeder was correlated with their material properties through a multivariate …

Impact of material properties and process variables on the residence time distribution in twin screw feeding equipment

B Van Snick, A Kumar, M Verstraeten… - International journal of …, 2019 - Elsevier
Screw feeders are integrated as dispensing units in most continuous manufacturing
platforms. Hence, characterizing and modelling the residence time distribution (RTD) of …

Impact of blend properties on die filling during tableting

B Van Snick, W Grymonpré, J Dhondt… - International Journal of …, 2018 - Elsevier
Based on characterization of a wide range of fillers and APIs, thirty divergent blends were
composed and subsequently compressed on a rotary tablet press, varying paddle speed …

An insight into predictive parameters of tablet capping by machine learning and multivariate tools

S Paul, Y Baranwal, YC Tseng - International Journal of Pharmaceutics, 2021 - Elsevier
Capping is the frequently observed mechanical defect in tablets arising from the sub-optimal
selection of the formulation composition and their robustness of response toward process …

Integration of biochar filtration into aquaponics: effects on particle size distribution and turbidity removal

Z Khiari, K Alka, S Kelloway, B Mason… - Agricultural Water …, 2020 - Elsevier
Small-and large-scale biochar-based filtrations were conducted to investigate the potential
of biochar as a low-cost renewable filtration medium in aquaponics. The small-scale …