Entry and exit of extracellular vesicles to and from the blood circulation

D Iannotta, AW Kijas, AE Rowan, J Wolfram - Nature Nanotechnology, 2024 - nature.com
Extracellular vesicles (EVs) are biological nanoparticles that promote intercellular
communication by delivering bioactive cargo over short and long distances. Short-distance …

Extracellular membrane vesicles in the three domains of life and beyond

S Gill, R Catchpole, P Forterre - FEMS microbiology reviews, 2019 - academic.oup.com
Cells from all three domains of life, Archaea, Bacteria and Eukarya, produce extracellular
vesicles (EVs) which are sometimes associated with filamentous structures known as …

Transport of extracellular vesicles across the blood-brain barrier: brain pharmacokinetics and effects of inflammation

WA Banks, P Sharma, KM Bullock, KM Hansen… - International journal of …, 2020 - mdpi.com
Extracellular vesicles can cross the blood–brain barrier (BBB), but little is known about
passage. Here, we used multiple-time regression analysis to examine the ability of 10 …

Mesenchymal stem cell-derived exosomes as a new therapeutic strategy for liver diseases

G Lou, Z Chen, M Zheng, Y Liu - Experimental & molecular medicine, 2017 - nature.com
The administration of mesenchymal stem cells (MSCs) as a therapy for liver disease holds
great promise. MSCs can differentiate into hepatocytes, reduce liver inflammation, promote …

Exosomes and other extracellular vesicles in host–pathogen interactions

JS Schorey, Y Cheng, PP Singh, VL Smith - EMBO reports, 2015 - embopress.org
An effective immune response requires the engagement of host receptors by pathogen‐
derived molecules and the stimulation of an appropriate cellular response. Therefore, a …

Biological properties of extracellular vesicles and their physiological functions

M Yáñez-Mó, PRM Siljander, Z Andreu… - Journal of …, 2015 - Taylor & Francis
In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of
intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity …

Exosomes surf on filopodia to enter cells at endocytic hot spots, traffic within endosomes, and are targeted to the ER

W Heusermann, J Hean, D Trojer, E Steib… - Journal of Cell …, 2016 - rupress.org
Exosomes are nanovesicles released by virtually all cells, which act as intercellular
messengers by transfer of protein, lipid, and RNA cargo. Their quantitative efficiency, routes …

Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity

HC Christianson, KJ Svensson… - Proceedings of the …, 2013 - National Acad Sciences
Extracellular vesicle (EV)-mediated intercellular transfer of signaling proteins and nucleic
acids has recently been implicated in the development of cancer and other pathological …

Therapeutic applications of extracellular vesicles: clinical promise and open questions

B György, ME Hung, XO Breakefield… - Annual review of …, 2015 - annualreviews.org
This review provides an updated perspective on rapidly proliferating efforts to harness
extracellular vesicles (EVs) for therapeutic applications. We summarize current knowledge …

Extracellular vesicles exploit viral entry routes for cargo delivery

HM Van Dongen, N Masoumi, KW Witwer… - Microbiology and …, 2016 - Am Soc Microbiol
Extracellular vesicles (EVs) have emerged as crucial mediators of intercellular
communication, being involved in a wide array of key biological processes. Eukaryotic cells …