Entry and exit of extracellular vesicles to and from the blood circulation
Extracellular vesicles (EVs) are biological nanoparticles that promote intercellular
communication by delivering bioactive cargo over short and long distances. Short-distance …
communication by delivering bioactive cargo over short and long distances. Short-distance …
Extracellular membrane vesicles in the three domains of life and beyond
S Gill, R Catchpole, P Forterre - FEMS microbiology reviews, 2019 - academic.oup.com
Cells from all three domains of life, Archaea, Bacteria and Eukarya, produce extracellular
vesicles (EVs) which are sometimes associated with filamentous structures known as …
vesicles (EVs) which are sometimes associated with filamentous structures known as …
Transport of extracellular vesicles across the blood-brain barrier: brain pharmacokinetics and effects of inflammation
Extracellular vesicles can cross the blood–brain barrier (BBB), but little is known about
passage. Here, we used multiple-time regression analysis to examine the ability of 10 …
passage. Here, we used multiple-time regression analysis to examine the ability of 10 …
Mesenchymal stem cell-derived exosomes as a new therapeutic strategy for liver diseases
The administration of mesenchymal stem cells (MSCs) as a therapy for liver disease holds
great promise. MSCs can differentiate into hepatocytes, reduce liver inflammation, promote …
great promise. MSCs can differentiate into hepatocytes, reduce liver inflammation, promote …
Exosomes and other extracellular vesicles in host–pathogen interactions
An effective immune response requires the engagement of host receptors by pathogen‐
derived molecules and the stimulation of an appropriate cellular response. Therefore, a …
derived molecules and the stimulation of an appropriate cellular response. Therefore, a …
Biological properties of extracellular vesicles and their physiological functions
In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of
intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity …
intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity …
Exosomes surf on filopodia to enter cells at endocytic hot spots, traffic within endosomes, and are targeted to the ER
W Heusermann, J Hean, D Trojer, E Steib… - Journal of Cell …, 2016 - rupress.org
Exosomes are nanovesicles released by virtually all cells, which act as intercellular
messengers by transfer of protein, lipid, and RNA cargo. Their quantitative efficiency, routes …
messengers by transfer of protein, lipid, and RNA cargo. Their quantitative efficiency, routes …
Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity
HC Christianson, KJ Svensson… - Proceedings of the …, 2013 - National Acad Sciences
Extracellular vesicle (EV)-mediated intercellular transfer of signaling proteins and nucleic
acids has recently been implicated in the development of cancer and other pathological …
acids has recently been implicated in the development of cancer and other pathological …
Therapeutic applications of extracellular vesicles: clinical promise and open questions
B György, ME Hung, XO Breakefield… - Annual review of …, 2015 - annualreviews.org
This review provides an updated perspective on rapidly proliferating efforts to harness
extracellular vesicles (EVs) for therapeutic applications. We summarize current knowledge …
extracellular vesicles (EVs) for therapeutic applications. We summarize current knowledge …
Extracellular vesicles exploit viral entry routes for cargo delivery
HM Van Dongen, N Masoumi, KW Witwer… - Microbiology and …, 2016 - Am Soc Microbiol
Extracellular vesicles (EVs) have emerged as crucial mediators of intercellular
communication, being involved in a wide array of key biological processes. Eukaryotic cells …
communication, being involved in a wide array of key biological processes. Eukaryotic cells …