Cardiovascular disease is a leading cause of death, and translational research is needed to
understand better mechanisms whereby the left ventricle responds to injury. Mouse models …

The gasotransmitters are a family of gaseous signaling molecules which are produced
endogenously and act at specific receptors to play imperative roles in physiologic and …

Oxidative stress, defined as an excess production of reactive oxygen species (ROS) relative
to antioxidant defense, has been shown to play an important role in the pathophysiology of …

Based on the “free radical theory” of disease, researchers have been trying to elucidate the
role of oxidative stress from free radicals in cardiovascular disease. Considerable data …

Outcomes for heart failure (HF) patients remain suboptimal. No known therapy improves
mortality in acute HF and HF with preserved ejection fraction; the most recent HF trial results …

Background We examined whether a fixed dose of both isosorbide dinitrate and hydralazine
provides additional benefit in blacks with advanced heart failure, a subgroup previously …

The crosstalk between endothelial cells and cardiomyocytes has emerged as a requisite for
normal cardiac development, but also a key pathogenic player during the onset and …

Background—Impaired flow-dependent, endothelium-mediated vasodilation (FDD) in
patients with chronic heart failure (CHF) results, at least in part, from accelerated …

Cardiac pressure load stimulates hypertrophy, often leading to chamber dilation and
dysfunction. ROS contribute to this process. Here we show that uncoupling of nitric oxide …

Wounding and healing are archaic principles, prerequisite for survival of any biologic
material. However, strategies to cope with wounding may be quite different among …