Phospholipase C (PLC) family members constitute a family of diverse enzymes. Thirteen
different family members have been cloned. These family members have unique structures …

Phosphoinositides (PI) form just a minor portion of the total phospholipid content in cells but
are significantly involved in cancer development and progression. In several cancer types …

Abstract Phosphatidylinositol-5-phosphate (PtdIns5P)− 4-kinases (PIP4Ks) are stress-
regulated phosphoinositide kinases able to phosphorylate PtdIns5P to PtdIns (4, 5) P2. In …

Phosphoinositides are rapidly turning-over phospholipids that play key roles in intracellular
signaling and modulation of membrane effectors. Through technical refinements we have …

Introduction Brain metastasis is a highly traumatic event in the progression of malignant
tumors, often symbolizing higher mortality. Metabolic alterations are hallmarks of cancer …

Symbioses between invertebrates and chemosynthetic bacteria are of fundamental
importance in deep‐sea ecosystems, but the mechanisms that enable their symbiont …

Cholangiocarcinoma is the second most common malignant tumor in the hepatobiliary
system. Compared with data on hepatocellular carcinoma, fewer public data and prognostic …

Liver cancer represents a global health challenge with worldwide growth. Hepatocellular
carcinoma (HCC) is the most common type of liver cancer. Indeed, approximately 90% of …

Phosphatidylinositol (PtdIns) metabolism is indispensable in eukaryotes. Phosphoinositides
(PIs) are phosphorylated derivatives of PtdIns and consist of seven species generated by …

Phosphoinositides (PtdInsPs) modulate a plethora of functions including signal transduction
and membrane trafficking. PtdInsPs are thought to consist of seven interconvertible species …