Nonresolving inflammation expands a heterogeneous population of myeloid suppressor
cells capable of inhibiting T cell function. This heterogeneity has confounded the functional …

We report a non-destructive biochemical technique, termed “Glyco-seek”, for analysis of O-
GlcNAcylated proteins. Glyco-seek combines chemoenzymatic labeling, proximity ligation …

Antibodies are widely exploited as research/diagnostic tools and therapeutics. Despite
providing exciting research opportunities, the multitude of available antibodies also offers a …

Traditional diagnostic neuropathology relies on subjective interpretation of visual data
obtained from a brightfield microscopy. This approach causes high variability, unsatisfactory …

Recombinant soluble TRAIL and agonistic antibodies against TRAIL receptors (DR4 and
DR5) are currently being created for clinical cancer therapy, due to their selective killing of …

FOXO family members (FOXOs: FOXO1, FOXO3, FOXO4 and FOXO6) are important
transcription factors and tumor suppressors controlling cell homeostasis and cell fate. They …

Antibodies are indispensible research tools, yet the scientific community has not adopted
standardized procedures to validate their specificity. Here we present a strategy to …

Commercial research antibodies are the most commonly used product in the life science
tools market, and their applications represent a significant investment of time and resources …

The process of making antibodies is costly and time-consuming. Commercial antibodies
offer a convenient solution. However, recent concerns have resulted in a National Institutes …

Recent developments of introducing stratified medicine/personal health care have led to an
increased demand for specific biomarkers. However, despite the myriads of biomarkers …