Interfacing living and synthetic cells as an emerging frontier in synthetic biology
Y Elani - Angewandte Chemie, 2021 - Wiley Online Library
The construction of artificial cells from inanimate molecular building blocks is one of the
grand challenges of our time. In addition to being used as simplified cell models to decipher …
grand challenges of our time. In addition to being used as simplified cell models to decipher …
Dynamic fusion of nucleic acid functionalized nano-/micro-cell-like containments: from basic concepts to applications
Membrane fusion processes play key roles in biological transformations, such as
endocytosis/exocytosis, signal transduction, neurotransmission, or viral infections, and …
endocytosis/exocytosis, signal transduction, neurotransmission, or viral infections, and …
Fluidic multivalent membrane nanointerface enables synergetic enrichment of circulating tumor cells with high efficiency and viability
The ubiquitous biomembrane interface, with its dynamic lateral fluidity, allows membrane-
bound components to rearrange and localize for high-affinity multivalent ligand–receptor …
bound components to rearrange and localize for high-affinity multivalent ligand–receptor …
Responsive core-shell DNA particles trigger lipid-membrane disruption and bacteria entrapment
Biology has evolved a variety of agents capable of permeabilizing and disrupting lipid
membranes, from amyloid aggregates, to antimicrobial peptides, to venom compounds …
membranes, from amyloid aggregates, to antimicrobial peptides, to venom compounds …
A coarse-grained simulation model for colloidal self-assembly via explicit mobile binders
Colloidal particles with mobile binding molecules constitute a powerful platform for probing
the physics of self-assembly. Binding molecules are free to diffuse and rearrange on the …
the physics of self-assembly. Binding molecules are free to diffuse and rearrange on the …
DNA-origami line-actants control domain organization and fission in synthetic membranes
Cells can precisely program the shape and lateral organization of their membranes using
protein machinery. Aiming to replicate a comparable degree of control, here we introduce …
protein machinery. Aiming to replicate a comparable degree of control, here we introduce …
Combinatorial entropy behaviour leads to range selective binding in ligand-receptor interactions
M Liu, A Apriceno, M Sipin, E Scarpa… - Nature …, 2020 - nature.com
From viruses to nanoparticles, constructs functionalized with multiple ligands display
peculiar binding properties that only arise from multivalent effects. Using statistical …
peculiar binding properties that only arise from multivalent effects. Using statistical …
Nanoarchitectonics horizons: materials for life sciences
Nanoarchitectonics relies on the fabrication of materials at the atomic/molecular level to
achieve the desired shape and function. Significant advances have been made in …
achieve the desired shape and function. Significant advances have been made in …
Self-assembly of DNA-grafted colloids: a review of challenges
DNA-mediated self-assembly of colloids has emerged as a powerful tool to assemble the
materials of prescribed structure and properties. The uniqueness of the approach lies in the …
materials of prescribed structure and properties. The uniqueness of the approach lies in the …
A synthetic signaling network imitating the action of immune cells in response to bacterial metabolism
State‐of‐the‐art bottom‐up synthetic biology allows to replicate many basic biological
functions in artificial‐cell‐like devices. To mimic more complex behaviors, however, artificial …
functions in artificial‐cell‐like devices. To mimic more complex behaviors, however, artificial …