The past two centuries have witnessed an unprecedented rise in human life expectancy.
Sustaining longer lives with reduced periods of disability will require an understanding of the …

Glaucoma is a leading cause of irreversible blindness worldwide. Primary open-angle
glaucoma (POAG), the most common type, is a complex inherited disorder that is …

Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …

Primary open-angle glaucoma (POAG) is a leading cause of irreversible vision loss, yet
much of the genetic risk remains unaccounted for, especially in African-Americans who have …

Primary open-angle glaucoma (POAG), the most common optic neuropathy, is a heritable
disease. Siblings of POAG cases have a ten-fold increased risk of developing the disease …

Juvenile open‐angle glaucoma (JOAG) is a severe type of glaucoma with onset before age
40 and dominant inheritance. Using exome sequencing we identified 3 independent families …

Elevated intraocular pressure (IOP) is a major risk factor for glaucoma, a leading cause of
blindness. IOP heritability has been estimated to up to 67%, and to date only 11 IOP loci …

Fibulin-3 (also known as EGF-containing fibulin extracellular matrix protein 1 (EFEMP1)) is a
secreted extracellular matrix glycoprotein, encoded by the EFEMP1 gene that belongs to the …

Background Age-related macular degeneration (AMD) is a common condition of vision loss
with disease development strongly influenced by environmental and genetic factors …

Glaucoma is a collection of diseases that lead to an irreversible vision loss due to damage of
retinal ganglion cells (RGCs). Although the underlying events leading to RGC death are not …