Insights into glomerular filtration and albuminuria
Glomerular Filtration and Albuminuria Chronic kidney diseases generally arise from a
disordered kidney filtration barrier within glomeruli. This review describes the roles of …
disordered kidney filtration barrier within glomeruli. This review describes the roles of …
The glomerular filtration barrier: a structural target for novel kidney therapies
IS Daehn, JS Duffield - Nature Reviews Drug Discovery, 2021 - nature.com
Loss of normal kidney function affects more than 10% of the population and contributes to
morbidity and mortality. Kidney diseases are currently treated with immunosuppressive …
morbidity and mortality. Kidney diseases are currently treated with immunosuppressive …
Coenzyme Q10 Supplementation in Aging and Disease
JD Hernández-Camacho, M Bernier… - Frontiers in …, 2018 - frontiersin.org
Coenzyme Q (CoQ) is an essential component of the mitochondrial electron transport chain
and an antioxidant in plasma membranes and lipoproteins. It is endogenously produced in …
and an antioxidant in plasma membranes and lipoproteins. It is endogenously produced in …
A single-gene cause in 29.5% of cases of steroid-resistant nephrotic syndrome
CE Sadowski, S Lovric, S Ashraf… - Journal of the …, 2015 - journals.lww.com
Steroid-resistant nephrotic syndrome (SRNS) is the second most frequent cause of ESRD in
the first two decades of life. Effective treatment is lacking. First insights into disease …
the first two decades of life. Effective treatment is lacking. First insights into disease …
Biochemistry of mitochondrial coenzyme Q biosynthesis
JA Stefely, DJ Pagliarini - Trends in biochemical sciences, 2017 - cell.com
Coenzyme Q (CoQ, ubiquinone) is a redox-active lipid produced across all domains of life
that functions in electron transport and oxidative phosphorylation and whose deficiency …
that functions in electron transport and oxidative phosphorylation and whose deficiency …
The cell biology of renal filtration
RP Scott, SE Quaggin - Journal of cell biology, 2015 - rupress.org
The function of the kidney, filtering blood and concentrating metabolic waste into urine, takes
place in an intricate and functionally elegant structure called the renal glomerulus. Normal …
place in an intricate and functionally elegant structure called the renal glomerulus. Normal …
Exploring the genetic basis of early-onset chronic kidney disease
A Vivante, F Hildebrandt - Nature Reviews Nephrology, 2016 - nature.com
The primary causes of chronic kidney disease (CKD) in children differ from those of CKD in
adults. In the USA the most common diagnostic groups of renal disease that manifest before …
adults. In the USA the most common diagnostic groups of renal disease that manifest before …
Mitochondrial dysfunction in inherited renal disease and acute kidney injury
Mitochondria are increasingly recognized as key players in genetic and acquired renal
diseases. Most mitochondrial cytopathies that cause renal symptoms are characterized by …
diseases. Most mitochondrial cytopathies that cause renal symptoms are characterized by …
[HTML][HTML] Genomic and clinical profiling of a national nephrotic syndrome cohort advocates a precision medicine approach to disease management
A Bierzynska, HJ McCarthy, K Soderquest, ES Sen… - Kidney international, 2017 - Elsevier
Steroid Resistant Nephrotic Syndrome (SRNS) in children and young adults has differing
etiologies with monogenic disease accounting for 2.9–30% in selected series. Using whole …
etiologies with monogenic disease accounting for 2.9–30% in selected series. Using whole …
[PDF][PDF] Mitochondrial protein interaction mapping identifies regulators of respiratory chain function
Mitochondria are essential for numerous cellular processes, yet hundreds of their proteins
lack robust functional annotation. To reveal functions for these proteins (termed MXPs), we …
lack robust functional annotation. To reveal functions for these proteins (termed MXPs), we …