Co-amorphous drug delivery systems have recently gained considerable interest in the
pharmaceutical field because of their potential to improve oral bioavailability of poorly water …

The amorphous solid state offers an improved apparent solubility and dissolution rate.
However, due to thermodynamic instability and recrystallization tendencies during …

In recent years, the coamorphous drug delivery system has been established as a promising
formulation approach for delivering poorly water-soluble drugs. The coamorphous solid is a …

Solubility is one of the major problems associated with most of the new chemical entities that
can be reasonably addressed by drug amorphization. However, being a high-energy form, it …

Hot-melt extrusion (HME) is a well-accepted and extensively studied method for preparing
numerous types of drug delivery systems and dosage forms. It offers several advantages: no …

Introduction Most new drug candidates under development are poorly water-soluble, which
are related to multiple pharmaceutical issues, increasing the bioavailability of these drugs by …

Amino acids are natural compounds that can be safely used in pharmaceutical applications.
Considering the great interest in the amino acids used in the pharmaceutical industry, this …

Hyaluronic acid (HA), as a hygroscopic and biocompatible molecule, has displayed unique
permeation enhancement in transdermal delivery systems. Hence, indomethacin (IND) was …

Curcumin (CUR) has gained increasing interest worldwide due to multiple biological
activities. However, the therapeutic application remains limited because of its low aqueous …

Amorphous solid dispersions (ASDs) are probably the most common and important
supersaturating drug delivery systems for the formulation of poorly water-soluble …