Ubiquitination (the covalent attachment of ubiquitin molecules to target proteins) is one of
the main post-translational modifications of proteins. Historically, the type of …

DJ-1 is a multifunctional protein associated with pathomechanisms implicated in different
chronic diseases including neurodegeneration, cancer and diabetes. Several of the …

The degeneration of substantia nigra (SN) dopamine (DA) neurons in sporadic Parkinson׳ s
disease (PD) is characterized by disturbed gene expression networks. Micro (mi) RNAs are …

DJ-1 is a cancer-and Parkinson's disease-associated protein that participates in different
intracellular signaling pathways to protect cells from toxic stresses. DJ-1 expression …

Simple Summary Parkinson's disease is a neurodegenerative disorder characterized by the
death of a specific subset of dopamine-producing neurons. This triggers problems with …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of
dopaminergic neurons in the substantia nigra. The pathological hallmark of PD is the …

The DJ-1 protein was originally linked with Parkinson's disease and is now known to have
antioxidant functions. The protein has three redox-sensitive cysteine residues, which are …

Parkinson's disease (PD) is a progressive neurodegenerative disorder for which only
symptomatic treatments are available. Both preclinical and clinical studies suggest that …

For the maintenance of cellular homeostasis and energy metabolism, an uninterrupted
supply of oxygen (O 2) is routinely required in the brain. However, under the impaired level …

The mammalian brain's complete dependence on oxygen for ATP production makes it highly
susceptible to hypoxia, at high altitudes or in clinical scenarios including anemia or …