From animal poisons and venoms to medicines: achievements, challenges and perspectives in drug discovery

KCF Bordon, CT Cologna, EC Fornari-Baldo… - Frontiers in …, 2020 - frontiersin.org
Animal poisons and venoms are comprised of different classes of molecules displaying wide-
ranging pharmacological activities. This review aims to provide an in-depth view of toxin …

Entomo-venomics: The evolution, biology and biochemistry of insect venoms

AA Walker, SD Robinson, DK Yeates, J Jin… - Toxicon, 2018 - Elsevier
The insects are a hyperdiverse class containing more species than all other animal groups
combined—and many employ venom to capture prey, deter predators and micro-organisms …

Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae)

AA Walker, SD Robinson, DJ Merritt… - Proceedings of the …, 2023 - National Acad Sciences
Larvae of the genus Megalopyge (Lepidoptera: Zygaenoidea: Megalopygidae), known as
asp or puss caterpillars, produce defensive venoms that cause severe pain. Here, we …

Caterpillar venom: A health hazard of the 21st century

A Seldeslachts, S Peigneur, J Tytgat - Biomedicines, 2020 - mdpi.com
Caterpillar envenomation is a global health threat in the 21st century. Every direct or indirect
contact with the urticating hairs of a caterpillar results in clinical manifestations ranging from …

Venoms of Lepidoptera: Evolution, Composition, and Molecular Modes of Action

AA Walker - Annual Review of Entomology, 2024 - annualreviews.org
Animal venoms are a focus of research due to the hazards they represent and to their
relationship to evolution and ecology, pharmacology, biodiscovery, and biotechnology …

Venomous caterpillars: From inoculation apparatus to venom composition and envenomation

IM Villas-Boas, G Bonfa, DV Tambourgi - Toxicon, 2018 - Elsevier
Envenomation by the larval or pupal stages of moths occurs when the victim presses their
hairs. They penetrate the subcutaneous tissue, releasing toxins such as proteolytic …

Lonomia obliqua Envenoming and Innovative Research

MP Alvarez-Flores, RN Gomes, D Trevisan-Silva… - Toxins, 2021 - mdpi.com
As a tribute to Butantan Institute in its 120th anniversary, this review describes some of the
scientific research efforts carried out in the study of Lonomia envenoming in Brazil, a country …

Regulation by gut bacteria of immune response, Bacillus thuringiensis susceptibility and hemolin expression in Plodia interpunctella

AA Orozco-Flores, JA Valadez-Lira, B Oppert… - Journal of Insect …, 2017 - Elsevier
Plodia interpunctella (Hübner) is an important stored grain insect pest worldwide, and the
first lepidopteran with reported resistance to Bacillus thuringiensis (Bt) toxins. Since gut …

Inflammatory progression in patients undergoing extracorporeal membrane oxygenation

Y Yao, H Kang, Y Cheng, X Su… - Current Molecular …, 2024 - benthamdirect.com
Extracorporeal membrane oxygenation (ECMO) is identified as a novel therapeutic strategy
that offers short-term support to the metabolism of the heart and lungs in humans. Recently …

Neuroprotective effect of rL osac on supplement‐deprived mouse cultured cortical neurons involves maintenance of monocarboxylate transporter MCT 2 protein levels

MP Alvarez‐Flores, A Hébert, C Gouelle… - Journal of …, 2019 - Wiley Online Library
Abstract The recombinant Lonomia obliqua Stuart‐factor activator (rL osac) is a recombinant
hemolin which belongs to the immunoglobulin superfamily of cell adhesion molecules. It is …