As competitive HMG-CoA reductase (HMGCR) inhibitors, statins not only reduce cholesterol
and improve cardiovascular risk, but also exhibit pleiotropic effects that are independent of …

The widespread clinical use of statins has contributed to significant reductions of
cardiovascular morbidity and mortality. Increasing preclinical and epidemiological …

Background Uterine corpus cancer is the most common invasive gynecologic cancer among
US women. Studies of endometrial cancers, which comprise approximately 90% of all …

After initial concerns regarding the association of statins with increased incidences of cancer
and elevated cancer-related mortality, there are now plenty of data on the antitumor …

Although it could be speculated that almost everything has been said concerning the use of
statins in cancer therapy, statins as anticancer drugs have both committed supporters and …

Experimental studies have demonstrated statin-induced toxicity for ovary and uterus.
However, the safety of statins on the functions of ovary and uterus in real-world clinical …

Hepatocellular carcinoma (HCC) is one of the most prevalent cancers worldwide and
accounts for more than 90% of primary liver cancer. The advent of immune checkpoint …

Mechanisms related to the potential beneficial effects of statins on cancer are mainly related
to the inhibition of the mevalonate pathway. The purpose of this study was to assess the …

Background The relationship between statin use and the risk of ovarian or endometrial
cancer remains controversial. Here, we investigated the relationship between statin use and …

Background Recent evidence has demonstrated that the salutary effect of statins on the
prevention and prognosis of cancers, including gynecologic cancers. However, due to the …