Cancer stem cells are a subset of cells within the tumor that possess the ability to self-renew
as well as differentiate into different cancer cell lineages. The exact mechanisms by which …

Organoids and stem-cell-based embryo models (SEMs) are imperfect organ or embryo
representations that explore a much larger space of possible forms, or morphospace …

Gastrulation is a key milestone in the development of an organism. It is a period of cell
proliferation and coordinated cellular rearrangement, that creates an outline of the body …

The cell type-specific expression of key transcription factors is central to development and
disease. Brachyury/T/TBXT is a major transcription factor for gastrulation, tailbud patterning …

Organisms across species differ in the relative size and complexity of their tissues to serve
the specific purposes of the host. Correct timing is a crucial ingredient in the development of …

Mammalian stem-cell-based models of embryo development (stembryos) hold great promise
in basic and applied research. However, considerable phenotypic variation despite identical …

Patterning and growth are fundamental features of embryonic development that must be
tightly coordinated during morphogenesis. As metabolism can control cell growth while also …

Pluripotent embryonic stem cells (ESCs) can develop into any cell type in the body. Yet, the
regulatory mechanisms that govern cell fate decisions during embryogenesis remain largely …

Highlights●Gastruloids are tractable and scalable in vitro models of fate-specification.●
Gastruloids are useful tools to study self-organisation and signalling hierarchy during …

PHD2 is essential in modulating HIF-1α levels upon oxygen fluctuations. Hypoxia, a
hallmark of uterus, and HIF-1α have recently emerged as opposing regulators of …