The neurocircuitry of fear, stress, and anxiety disorders

LM Shin, I Liberzon - Neuropsychopharmacology, 2010 - nature.com
Anxiety disorders are a significant problem in the community, and recent neuroimaging
research has focused on determining the brain circuits that underlie them. Research on the …

Neurocircuitry models of posttraumatic stress disorder and beyond: a meta-analysis of functional neuroimaging studies

R Patel, RN Spreng, LM Shin, TA Girard - Neuroscience & Biobehavioral …, 2012 - Elsevier
Over the past two decades a relatively large number of studies have investigated the
functional neuroanatomy of posttraumatic stress disorder (PTSD). However, findings are …

Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia

A Etkin, TD Wager - American journal of Psychiatry, 2007 - Am Psychiatric Assoc
Objective: The study of human anxiety disorders has benefited greatly from functional
neuroimaging approaches. Individual studies, however, vary greatly in their findings. The …

Treatment for PTSD related to childhood abuse: A randomized controlled trial

M Cloitre, KC Stovall-McClough… - American journal of …, 2010 - Am Psychiatric Assoc
Objective Posttraumatic stress disorder (PTSD) related to childhood abuse is associated
with features of affect regulation and interpersonal disturbances that substantially contribute …

Amygdala, medial prefrontal cortex, and hippocampal function in PTSD

LM Shin, SL Rauch, RK Pitman - … of the New York Academy of …, 2006 - Wiley Online Library
The last decade of neuroimaging research has yielded important information concerning the
structure, neurochemistry, and function of the amygdala, medial prefrontal cortex, and …

Quantitative meta-analysis of neural activity in posttraumatic stress disorder

JP Hayes, SM Hayes, AM Mikedis - Biology of mood & anxiety disorders, 2012 - Springer
Background In recent years, neuroimaging techniques such as functional magnetic
resonance imaging (fMRI) and positron emission tomography (PET) have played a …

Current status on behavioral and biological markers of PTSD: a search for clarity in a conflicting literature

PR Zoladz, DM Diamond - Neuroscience & Biobehavioral Reviews, 2013 - Elsevier
Extensive research has identified stereotypic behavioral and biological abnormalities in post-
traumatic stress disorder (PTSD), such as heightened autonomic activity, an exaggerated …

How the neurocircuitry and genetics of fear inhibition may inform our understanding of PTSD

T Jovanovic, KJ Ressler - American Journal of Psychiatry, 2010 - Am Psychiatric Assoc
Exposure to traumatic events that produce extreme fear and horror is all too common in both
military and civilian populations, but not all individuals develop posttraumatic stress disorder …

The functional neuroanatomy of PTSD: a critical review

I Liberzon, CS Sripada - Progress in brain research, 2007 - Elsevier
Neuroimaging provides an opportunity to understand core processes that mediate the
experience of emotions in healthy individuals as well as dysregulation of these processes in …

Serotonin, amygdala and fear: assembling the puzzle

M Bocchio, SB McHugh, DM Bannerman… - Frontiers in neural …, 2016 - frontiersin.org
The fear circuitry orchestrates defense mechanisms in response to environmental threats.
This circuitry is evolutionarily crucial for survival, but its dysregulation is thought to play a …