Natural products have proven their value as drugs that can be therapeutically beneficial in
the treatment of various diseases. However, most natural products have low solubility and …

Only a minority of rheumatoid arthritis (RA) patients achieve disease remission, so the
exploration of additional pathogenic factors and the development of new therapeutics are …

Intracellular cargo delivery, the introduction of small molecules, proteins, and nucleic acids
into a specific targeted site in a biological system, is an important strategy for deciphering …

Nanomedicines, emerging as an innovative category of cancer therapeutics, have garnered
increasing attention from both researchers and the broader public. However, despite this …

Oral diseases are prevalent but challenging diseases owing to the highly movable and wet,
microbial and inflammatory environment. Polymeric materials are regarded as one of the …

Hepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide.
Sorafenib (Sf) is currently the first-line treatment for HCC. However, due to the side effects …

Breast cancer (BC) is the most prevalent malignant tumor, surpassing lung cancer as the
most frequent malignancy in women. Drug resistance, metastasis, and immune escape are …

Oral cancer is notoriously painful. Activation of protease-activated receptor 2 (PAR 2,
encoded by F2RL1) by proteases in the cancer microenvironment is implicated in oral …

Neuroblastoma, a pediatric cancer originating from neural crest tissues of the sympathetic
nervous system, poses significant treatment challenges due to its molecular diversity and …

The therapeutic outcomes of patients with eosinophilic chronic rhinosinusitis (ECRS) remain
unsatisfactory, largely because the underlying mechanisms of eosinophilic inflammation are …