Epithelial–mesenchymal plasticity (EMP) enables cells to interconvert between several
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …

The Hippo-Yes-associated protein (YAP) signaling network plays a central role as an
integrator of signals that control cellular proliferation and differentiation. The past several …

Embryonic cells exhibit diverse metabolic states. Recent studies have demonstrated that
metabolic reprogramming drives changes in cell identity by affecting gene expression …

Rationale: We found that a subset of signal transducer and activator of transcription 3
(STAT3) translocated into mitochondria in phagocytes, including macrophages isolated from …

Stem cells have self-renewal capacities and the ability to give rise to differentiated cells
thereby sustaining tissues during homeostasis and injury. This structural hierarchy extends …

Resistance of melanoma to targeted therapy and immunotherapy is linked to metabolic
rewiring. Here, we show that increased fatty acid oxidation (FAO) during prolonged BRAF …

Mechanical forces are integral to development—from the earliest stages of embryogenesis
to the construction and differentiation of complex organs. Advances in imaging and …

Neural crest cells (NCCs) are multipotent stem cells that can differentiate into multiple cell
types, including the osteoblasts and chondrocytes, and constitute most of the craniofacial …

Attention has long focused on the actin cytoskeleton as a unit capable of organizing into
ensembles that control cell shape, polarity, migration and the establishment of intercellular …

Cancer cells have the plasticity to adjust their metabolic phenotypes for survival and
metastasis. A developmental programme known as epithelial-to-mesenchymal transition …