Abstract Purpose of Review Mitochondria play various roles that are important for cell
function and survival; therefore, significant mitochondrial dysfunction may have chronic …

Benzene causes acute myeloid leukemia and probably other hematological malignancies.
As benzene also causes hematotoxicity even in workers exposed to levels below the US …

Accumulation of mitochondrial DNA (mtDNA) mutations leads to alterations of mitochondrial
biogenesis and function that might produce a decrease in mtDNA content within cells. This …

Background Oxidative stress generation is a primary mechanism mediating the effects of
Particulate Matter (PM) on human health. Although mitochondria are both the major …

It has been proposed that the copy number of mitochondria DNA (mtDNA) per cell reflects
gene–environment interactions between unknown hereditary factors and exposures …

Increases in smoking, urbanization and the persistence of burning unrefined fuel indoors in
low-and middle-income countries (more than 80% of the world's population) have led to a …

Background: Benzene is an established leukemogen at high exposure levels. Although low-
level benzene exposure is widespread and may induce oxidative damage, no mechanistic …

Benzene is a widespread volatile compound and an environmental contaminant. Since it
causes important toxic effects in workers exposed to low levels, long‐term exposure to this …

Mitochondrial DNA (mtDNA) copy number is increased in patients with chronic lymphocytic
leukemia (CLL), in Burkitt lymphoma and Epstein-Barr virus–transformed lymphoblastoid …

Background Ambient particulate matter (PM) has been associated with mitochondrial
damage and dysfunction caused by excessive oxidative stress, but the associations …