KCNMA1 encodes the pore-forming α subunit of the “Big K+”(BK) large conductance calcium
and voltage-activated K+ channel. BK channels are widely distributed across tissues …

Substantial experimental evidences support the hypothesis that dietary flavonoid intake has
a favourable impact on cardiovascular diseases such as systemic, arterial hypertension and …

Potassium (K+) channels have been evolutionarily tuned for activation by diverse biological
stimuli, and pharmacological activation is thought to target these specific gating …

ABSTRACT KCNMA1-linked channelopathy is an emerging neurological disorder
characterized by heterogeneous and overlapping combinations of movement disorder …

This review integrates from the single muscle fibre to exercising human the current
understanding of the role of skeletal muscle for whole-body potassium (K+) regulation, and …

Ca2+-and voltage-gated K+ channels of large conductance (BK channels) are expressed in
a diverse variety of both excitable and inexcitable cells, with functional properties …

The gating mechanism of transmembrane ion channels is crucial for understanding how
these proteins control ion flow across membranes in various physiological processes. Big …

Inactivation is the process by which ion channels terminate ion flux through their pores while
the opening stimulus is still present. In neurons, inactivation of both sodium and potassium …

Cellular Signal Processing offers a unifying view of cell signaling based on the concept that
protein interactions act as sophisticated data processing networks that govern intracellular …

We celebrate this year the 50th anniversary of the first electrophysiological recordings of the
gating currents from voltage-dependent ion channels done in 1973. This retrospective tries …