One of the two chromosomal breakage events in recurring translocations in B cell
neoplasms is often due to the recombination-activating gene complex (RAG complex) …

Deoxynucleoside triphosphates (dNTPs) are crucial for the replication and maintenance of
genomic information within cells. The balance of the dNTP pool involves several cellular …

The prenylated form of the human 2′-5′-oligoadenylate synthetase 1 (OAS1) protein has
been shown to potently inhibit the replication of Severe Acute Respiratory Syndrome …

Precision genome editing has become a reality with the discovery of base editors. Cytosine
base editor (CBE) technologies are improving rapidly but are mostly optimized for TC …

The apolipoprotein B mRNA-editing catalytic polypeptide-like (APOBEC) family specifies
multiple cytidine deaminases. In mammals, a minimum of 5 genes encode APOBECs 1, 2, 3 …

The APOBEC3 family of DNA cytosine deaminases comprises an important arm of the innate
antiviral defense system. The gamma-herpesviruses Epstein-Barr virus and Kaposi's …

The apolipoprotein B mRNA editing enzyme catalytic polypeptide-like (APOBEC) family
consists of cytosine deaminases implicated in diverse and important biological functions …

Abstract Highlights RNA-free APOBEC3 (A3) can enter the nucleus, leading to genomic
mutations. Three E3 ligases specifically bind the RNA-binding domain of nuclear A3s …

Viruses are obligate intracellular pathogens that hijack host cell machinery to facilitate
replication and suppress innate immune responses. Because of their limited genetic …

Enzymes require specificity for substrates to overcome passive diffusion and efficiently
conduct complex chemical reactions in biological systems. Only when binding to the correct …