Birth and death of histone mRNAs
WF Marzluff, KP Koreski - Trends in Genetics, 2017 - cell.com
In metazoans, histone mRNAs are not polyadenylated but end in a conserved stem-loop.
Stem-loop binding protein (SLBP) binds to the stem-loop and is required for all steps in …
Stem-loop binding protein (SLBP) binds to the stem-loop and is required for all steps in …
RNA structures as mediators of neurological diseases and as drug targets
RNAs adopt diverse folded structures that are essential for function and thus play critical
roles in cellular biology. A striking example of this is the ribosome, a complex, three …
roles in cellular biology. A striking example of this is the ribosome, a complex, three …
Development of force field parameters for the simulation of single-and double-stranded DNA molecules and DNA–protein complexes
Although molecular dynamics (MD) simulations have been used extensively to study the
structural dynamics of proteins, the role of MD simulation in studies of nucleic acid based …
structural dynamics of proteins, the role of MD simulation in studies of nucleic acid based …
Structure of an active human histone pre-mRNA 3′-end processing machinery
The 3′-end processing machinery for metazoan replication-dependent histone precursor
messenger RNAs (pre-mRNAs) contains the U7 small nuclear ribonucleoprotein and shares …
messenger RNAs (pre-mRNAs) contains the U7 small nuclear ribonucleoprotein and shares …
Intra-and inter-molecular regulation by intrinsically-disordered regions governs PUF protein RNA binding
PUF proteins are characterized by globular RNA-binding domains. They also interact with
partner proteins that modulate their RNA-binding activities. Caenorhabditis elegans PUF …
partner proteins that modulate their RNA-binding activities. Caenorhabditis elegans PUF …
Intrinsically disordered electronegative clusters improve stability and binding specificity of RNA-binding proteins
S Zaharias, Z Zhang, K Davis, T Fargason… - Journal of Biological …, 2021 - ASBMB
RNA-binding proteins play crucial roles in various cellular functions and contain abundant
disordered protein regions. The disordered regions in RNA-binding proteins are rich in …
disordered protein regions. The disordered regions in RNA-binding proteins are rich in …
The translational repressor Glorund uses interchangeable RNA recognition domains to recognize Drosophila nanos
MS Warden, EF DeRose, JV Tamayo… - Nucleic acids …, 2023 - academic.oup.com
Abstract The Drosophila melanogaster protein Glorund (Glo) represses nanos (nos)
translation and uses its quasi-RNA recognition motifs (qRRMs) to recognize both G-tract and …
translation and uses its quasi-RNA recognition motifs (qRRMs) to recognize both G-tract and …
RNAcompete-S: Combined RNA sequence/structure preferences for RNA binding proteins derived from a single-step in vitro selection
RNA-binding proteins recognize RNA sequences and structures, but there is currently no
systematic and accurate method to derive large (> 12 base) motifs de novo that reflect a …
systematic and accurate method to derive large (> 12 base) motifs de novo that reflect a …
Application of tyrosine-tryptophan fluorescence resonance energy transfer in monitoring protein size changes
Monitoring protein size changes has versatile applications in studying protein
folding/unfolding, conformational rearrangements, and ligand binding. Traditionally, FRET …
folding/unfolding, conformational rearrangements, and ligand binding. Traditionally, FRET …
Characterization of binding of LARP6 to the 5'stem-loop of collagen mRNAs: implications for synthesis of type I collagen
L Stefanovic, L Longo, Y Zhang, B Stefanovic - RNA biology, 2014 - Taylor & Francis
Type I collagen is composed of 2 polypeptides, α1 (I) and α2 (I), which fold into triple helix.
Collagen α1 (I) and α2 (I) mRNAs have a conserved stem-loop structure in their 5'UTRs, the …
Collagen α1 (I) and α2 (I) mRNAs have a conserved stem-loop structure in their 5'UTRs, the …