Selective vulnerability of specific brain regions and cell populations is a hallmark of
neurodegenerative disorders. Mechanisms of selective vulnerability involve neuronal …

The complement system is increasingly recognized as a key player in the synapse loss and
cognitive impairments observed in Alzheimer's disease (AD). In particular, the process of …

Tau hyperphosphorylation and aggregation is a common feature of many dementia-causing
neurodegenerative diseases. Tau can be phosphorylated at up to 85 different sites, and …

Synapse loss is one of the most critical features in Alzheimer's disease (AD) and correlates
with cognitive decline. Astrocytes mediate synapse elimination through multiple EGF-like …

Microglial endolysosomal (dys) function is strongly implicated in neurodegenerative
disease. Transcriptomic studies show that a microglial state characterised by a set of genes …

Microglia are the resident immune cells of the central nervous system (CNS) and as such
play crucial roles in regulating brain homeostasis. Their presence in neurodegenerative …

Neuromyelitis optica (NMO) is a severe autoimmune inflammatory disease of the central
nervous system that affects motor function and causes relapsing disability. Human umbilical …

Proteins exhibiting prion-like properties are implicated in tauopathies. The prion-like traits of
tau influence disease progression and correlate with severity. Techniques to measure tau …

Research indicates that brain-region-specific synapse loss and dysfunction are early
hallmarks and stronger neurobiological correlates of cognitive decline in Alzheimer's …

Background: Alzheimer's disease (AD) is a progressive neurodegeneration disease.
Physical activity is one of the most promising modifiable lifestyles that can be effective in …