The sequencing of chromosome 21 and the use of models of Down's syndrome in mice have
allowed us to relate genes and sets of genes to the neuropathogenesis of this syndrome …

Folate being an important vitamin of B Complex group in our diet plays an important role not
only in the synthesis of DNA but also in the maintenance of methylation reactions in the …

Down syndrome (DS) is the most commonly identified genetic form of mental retardation and
the leading cause of specific birth defects and medical conditions. Traditional …

The influence of folate nutritional status on various pregnancy outcomes has long been
recognized. Studies conducted in the 1950s and 1960s led to the recognition of prenatal …

Geographical and ethnic variation of the 677C>T allele of 5,10 methylenetetrahydrofolate
reductase (MTHFR): findings from over 7000 newborns from 16 areas world wide | Journal of …

The importance of folate in reproduction can be appreciated by considering that the
existence of the vitamin was first suspected from efforts to explain a potentially fatal …

Spina bifida, anencephaly, and encephalocele are commonly grouped together and termed
neural tube defects (NTD). Failure of closure of the neural tube during development results …

Epidemiologic and mechanistic evidence suggests that folate is involved in colorectal
neoplasia. Some polymorphic genes involved in folate metabolism …

Although developmental delays affect learning, language, and behavior, some evidence
suggests the presence of disturbances in metabolism are associated with psychiatric …

During the fifteen years since the bestselling first edition of Folate in Health and Disease
was published, there have been thousands of new research studies related to folate and its …