Chronic liver injury leads to liver inflammation and fibrosis, through which activated
myofibroblasts in the liver secrete extracellular matrix proteins that generate the fibrous scar …

Cancer cell identity and plasticity are required in transition states, such as epithelial–
mesenchymal transition (EMT) and mesenchymal–epithelial transition (MET), in primary …

The tumour microenvironment, also termed the tumour stroma or tumour mesenchyme,
includes fibroblasts, immune cells, blood vessels and the extracellular matrix and …

Tumorigenesis is a complex and dynamic process, consisting of three stages: initiation,
progression, and metastasis. Tumors are encircled by extracellular matrix (ECM) and …

The S100 family of proteins contains 25 known members that share a high degree of
sequence and structural similarity. However, only a limited number of family members have …

The role of epithelial-to-mesenchymal transition (EMT) in metastasis is a longstanding
source of debate, largely owing to an inability to monitor transient and reversible EMT …

The epithelial-mesenchymal transition (EMT) describes the global process by which
stationary epithelial cells undergo phenotypic changes, including the loss of cell-cell …

Metastasis consists of hallmark events, including Epithelial-Mesenchymal Transition (EMT),
angiogenesis, initiation of inflammatory tumor microenvironment, and malfunctions in …

Hepatocellular carcinoma (HCC) is one of the most aggressive types of cancer and lacks
effective therapeutic approaches. Most HCC develops in the setting of chronic liver injury …

Fibroblasts regulate the structure and function of healthy tissues, participate transiently in
tissue repair after acute inflammation, and assume an aberrant stimulatory role during …