The expanding universe of PARP1-mediated molecular and therapeutic mechanisms
D Huang, WL Kraus - Molecular cell, 2022 - cell.com
ADP-ribosylation (ADPRylation) is a post-translational modification of proteins catalyzed by
ADP-ribosyl transferase (ART) enzymes, including nuclear PARPs (eg, PARP1 and PARP2) …
ADP-ribosyl transferase (ART) enzymes, including nuclear PARPs (eg, PARP1 and PARP2) …
Poly (ADP-ribosyl) ation by PARP1: reaction mechanism and regulatory proteins
EE Alemasova, OI Lavrik - Nucleic acids research, 2019 - academic.oup.com
Abstract Poly (ADP-ribosyl) ation (PARylation) is posttranslational modification of proteins by
linear or branched chains of ADP-ribose units, originating from NAD+. The central enzyme …
linear or branched chains of ADP-ribose units, originating from NAD+. The central enzyme …
Regulated necrosis: the expanding network of non-apoptotic cell death pathways
TV Berghe, A Linkermann, S Jouan-Lanhouet… - … reviews Molecular cell …, 2014 - nature.com
Cell death research was revitalized by the understanding that necrosis can occur in a highly
regulated and genetically controlled manner. Although RIPK1 (receptor-interacting protein …
regulated and genetically controlled manner. Although RIPK1 (receptor-interacting protein …
PARP1 associates with R-loops to promote their resolution and genome stability
PARP1 is a DNA-dependent ADP-Ribose transferase with ADP-ribosylation activity that is
triggered by DNA breaks and non-B DNA structures to mediate their resolution. PARP1 was …
triggered by DNA breaks and non-B DNA structures to mediate their resolution. PARP1 was …
[HTML][HTML] Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells
Replication fork reversal protects forks from breakage after poisoning of Topoisomerase 1.
We here investigated fork progression and chromosomal breakage in human cells in …
We here investigated fork progression and chromosomal breakage in human cells in …
Metal complex interactions with DNA
Increasing numbers of DNA structures are being revealed using biophysical, spectroscopic
and genomic methods. The diversity of transition metal complexes is also growing, as the …
and genomic methods. The diversity of transition metal complexes is also growing, as the …
Phagocytosis of necrotic debris at sites of injury and inflammation
Clearance of cellular debris is required to maintain the homeostasis of multicellular
organisms. It is intrinsic to processes such as tissue growth and remodeling, regeneration …
organisms. It is intrinsic to processes such as tissue growth and remodeling, regeneration …
Structural basis for DNA damage–dependent poly (ADP-ribosyl) ation by human PARP-1
MF Langelier, JL Planck, S Roy, JM Pascal - Science, 2012 - science.org
Poly (ADP-ribose) polymerase–1 (PARP-1)(ADP, adenosine diphosphate) has a modular
domain architecture that couples DNA damage detection to poly (ADP-ribosyl) ation activity …
domain architecture that couples DNA damage detection to poly (ADP-ribosyl) ation activity …
PARP-1 activation requires local unfolding of an autoinhibitory domain
JM Dawicki-McKenna, MF Langelier, JE DeNizio… - Molecular cell, 2015 - cell.com
Summary Poly (ADP-ribose) polymerase-1 (PARP-1) creates the posttranslational
modification PAR from substrate NAD+ to regulate multiple cellular processes. DNA breaks …
modification PAR from substrate NAD+ to regulate multiple cellular processes. DNA breaks …
Poly (ADP-ribose): novel functions for an old molecule
V Schreiber, F Dantzer, JC Ame… - Nature reviews Molecular …, 2006 - nature.com
The addition to proteins of the negatively charged polymer of ADP-ribose (PAR), which is
synthesized by PAR polymerases (PARPs) from NAD+, is a unique post-translational …
synthesized by PAR polymerases (PARPs) from NAD+, is a unique post-translational …