Proteins are the key players in many cellular processes. Their composition, trafficking, and
interactions underlie the dynamic processes of life. Furthermore, diseases are frequently …

Radioresistance is regarded as the main barrier to effective radiotherapy in lung cancer.
However, the underlying mechanisms of radioresistance remain elusive. Here, we show that …

Despite extensive efforts and continual progress in research and medicine, outcomes for
patients with high-grade glioma remain exceptionally poor. Over the past decade, research …

Abstract UBE2O, an E2/E3 hybrid ubiquitin-protein ligase, has been implicated in the
regulation of adipogenesis, erythroid differentiation, and tumor proliferation. However, its …

Radiochemoresistance is considered the main cause of local recurrence and distant
metastasis in lung cancer. However, the underlying mechanisms of radiochemoresistance …

Several studies have described functional peptides encoded in RNA that are considered to
be noncoding. Telomerase RNA together with telomerase reverse transcriptase and …

Abstract Phosphoinositide 3-kinase (PI3K) activity is aberrantly activated in nasopharyngeal
carcinoma. However, the underlying mechanisms remain unclear. Here, we found that …

Distant metastasis is the leading cause of treatment failure in patients with hepatocellular
carcinoma (HCC). However, the underlying mechanisms have not been fully elucidated …

Cancer cells inevitably develop radioresistance during lung adenocarcinoma radiotherapy.
However, the mechanisms are incompletely clarified. In this study, we show that FIBP protein …

Purpose Tumor resistance to radiation therapy is a therapeutic challenge in the treatment of
patients with non-small cell lung cancer. Cyclin-dependent kinase 5 (CDK5) has been …