Recent progress in mass spectrometry proteomics for biomedical research
Proteins are the key players in many cellular processes. Their composition, trafficking, and
interactions underlie the dynamic processes of life. Furthermore, diseases are frequently …
interactions underlie the dynamic processes of life. Furthermore, diseases are frequently …
[HTML][HTML] USP9X-mediated KDM4C deubiquitination promotes lung cancer radioresistance by epigenetically inducing TGF-β2 transcription
X Jie, WP Fong, R Zhou, Y Zhao, Y Zhao… - Cell Death & …, 2021 - nature.com
Radioresistance is regarded as the main barrier to effective radiotherapy in lung cancer.
However, the underlying mechanisms of radioresistance remain elusive. Here, we show that …
However, the underlying mechanisms of radioresistance remain elusive. Here, we show that …
[HTML][HTML] Revisiting CDK inhibitors for treatment of glioblastoma multiforme
D Lubanska, L Porter - Drugs in R&D, 2017 - Springer
Despite extensive efforts and continual progress in research and medicine, outcomes for
patients with high-grade glioma remain exceptionally poor. Over the past decade, research …
patients with high-grade glioma remain exceptionally poor. Over the past decade, research …
[HTML][HTML] UBE2O targets Mxi1 for ubiquitination and degradation to promote lung cancer progression and radioresistance
Y Huang, X Yang, Y Lu, Y Zhao, R Meng… - Cell Death & …, 2021 - nature.com
Abstract UBE2O, an E2/E3 hybrid ubiquitin-protein ligase, has been implicated in the
regulation of adipogenesis, erythroid differentiation, and tumor proliferation. However, its …
regulation of adipogenesis, erythroid differentiation, and tumor proliferation. However, its …
CDK20 interacts with KEAP1 to activate NRF2 and promotes radiochemoresistance in lung cancer cells
Q Wang, J Ma, Y Lu, S Zhang, J Huang, J Chen, JX Bei… - Oncogene, 2017 - nature.com
Radiochemoresistance is considered the main cause of local recurrence and distant
metastasis in lung cancer. However, the underlying mechanisms of radiochemoresistance …
metastasis in lung cancer. However, the underlying mechanisms of radiochemoresistance …
Protein encoded in human telomerase RNA is involved in cell protective pathways
M Rubtsova, Y Naraykina, D Vasilkova… - Nucleic Acids …, 2018 - academic.oup.com
Several studies have described functional peptides encoded in RNA that are considered to
be noncoding. Telomerase RNA together with telomerase reverse transcriptase and …
be noncoding. Telomerase RNA together with telomerase reverse transcriptase and …
LZTS2 inhibits PI3K/AKT activation and radioresistance in nasopharyngeal carcinoma by interacting with p85
S Xu, Y Li, Y Lu, J Huang, J Ren, S Zhang, Z Yin… - Cancer letters, 2018 - Elsevier
Abstract Phosphoinositide 3-kinase (PI3K) activity is aberrantly activated in nasopharyngeal
carcinoma. However, the underlying mechanisms remain unclear. Here, we found that …
carcinoma. However, the underlying mechanisms remain unclear. Here, we found that …
[HTML][HTML] β-Trcp and CK1δ-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma
Y Lu, X Li, H Liu, J Xue, Z Zeng, X Dong, T Zhang… - Oncogene, 2021 - nature.com
Distant metastasis is the leading cause of treatment failure in patients with hepatocellular
carcinoma (HCC). However, the underlying mechanisms have not been fully elucidated …
carcinoma (HCC). However, the underlying mechanisms have not been fully elucidated …
[HTML][HTML] FIBP interacts with transcription factor STAT3 to induce EME1 expression and drive radioresistance in lung adenocarcinoma
Y Xu, J Li, K Zhu, Y Zeng, J Chen, X Dong… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Cancer cells inevitably develop radioresistance during lung adenocarcinoma radiotherapy.
However, the mechanisms are incompletely clarified. In this study, we show that FIBP protein …
However, the mechanisms are incompletely clarified. In this study, we show that FIBP protein …
[HTML][HTML] CDK5 activates hippo signaling to confer resistance to radiation therapy via upregulating TAZ in lung cancer
Y Zeng, Q Liu, Y Wang, C Tian, Q Yang, Y Zhao… - International Journal of …, 2020 - Elsevier
Purpose Tumor resistance to radiation therapy is a therapeutic challenge in the treatment of
patients with non-small cell lung cancer. Cyclin-dependent kinase 5 (CDK5) has been …
patients with non-small cell lung cancer. Cyclin-dependent kinase 5 (CDK5) has been …