The RNA recognition motif (RRM), also known as RNA‐binding domain (RBD) or
ribonucleoprotein domain (RNP) is one of the most abundant protein domains in eukaryotes …

The C-terminal repeat domain (CTD), an unusual extension appended to the C terminus of
the largest subunit of RNA polymerase II, serves as a flexible binding scaffold for numerous …

Set2 methylates Lys36 of histone H3. We show here that yeast Set2 copurifies with RNA
polymerase II (RNAPII). Chromatin immunoprecipitation analyses demonstrated that Set2 …

The largest subunit of RNA polymerase II contains a unique C-terminal domain important for
coupling of transcription and mRNA processing. This domain consists of a repeated …

WW domains are small protein modules composed of approximately 40 amino acids. These
domains fold as a stable, triple stranded β-sheet and recognize proline-containing ligands …

One particularly abundant group of modular recognition domains consists of those that bind
proline-rich motifs. Such modules, including the SH3, WW, and EVH1 domains, play a …

How does the C-terminal domain (CTD) of RNA polymerase II interact specifically with
multiple targets? A recent paper describing the structure of this domain with a mRNA …

BCL6 encodes a transcription factor that represses genes necessary for the terminal
differentiation of lymphocytes within germinal centers, and the misregulated expression of …

The capacity for exquisite regulation of ubiquitylation provides eukaryotic cells with a means
to fine-tune both protein function and levels. This complex set of processes affects myriad …

Members of the TGF-β family of growth factors signal from the cell surface through
serine/threonine kinase receptors. Intracellular propagation of the signal occurs by …