The lungs are constantly exposed to inhaled debris, allergens, pollutants, commensal or
pathogenic microorganisms, and respiratory viruses. As a result, innate and adaptive …

Despite the great strides in healthcare during the last century, some challenges still
remained unanswered. The development of multi-drug resistant bacteria, the alarming …

Insects produce a large repertoire of antimicrobial peptides (AMPs) as the first line of
defense against bacteria, viruses, fungi or parasites. These peptides are produced from a …

The advent of Cystic fibrosis transmembrane receptor (CFTR) modulators in 2012 was a
critical event in the history of cystic fibrosis (CF) treatment. Unlike traditional therapies that …

Cystic fibrosis (CF) is caused by defects in an anion channel, the cystic fibrosis
transmembrane conductance regulator (CFTR). Recently, a new airway epithelial cell type …

Natural antimicrobial peptides (AMPs) are promising candidates for the development of a
new generation of antimicrobials to combat antibiotic-resistant pathogens. They have found …

The recent epidemic caused by aerosolized SARS-CoV-2 virus illustrates the importance
and vulnerability of the mucosal epithelial barrier against infection. Antimicrobial proteins …

Antibiotic resistance is a serious health and social problem that will have a substantial
impact in the coming years on the world health and economy. Thus, the increasing demand …

The respiratory mucus, a viscoelastic gel, effectuates a primary line of the airway defense
when operated by the mucociliary clearance. In chronic respiratory diseases (CRDs), such …

Abstract Background Antimicrobial peptides (AMPs) are a diverse class of molecules that
represent a vital part of innate immunity. AMPs are evolutionarily conserved molecules that …