[HTML][HTML] Intrinsic mechanism and pharmacologic treatments of noise-induced hearing loss
K Xu, B Xu, J Gu, X Wang, D Yu, Y Chen - Theranostics, 2023 - ncbi.nlm.nih.gov
Noise accounts for one-third of hearing loss worldwide. Regretfully, noise-induced hearing
loss (NIHL) is deemed to be irreversible due to the elusive pathogenic mechanisms that …
loss (NIHL) is deemed to be irreversible due to the elusive pathogenic mechanisms that …
[HTML][HTML] The apelinergic system: apelin, ELABELA, and APJ action on cell apoptosis: anti-apoptotic or pro-apoptotic effect?
N Respekta, K Pich, M Dawid, E Mlyczyńska… - Cells, 2022 - mdpi.com
The apelinergic system comprises two peptide ligands, apelin and ELABELA, and their
cognate G-protein-coupled receptor, the apelin receptor APJ. Apelin is a peptide that was …
cognate G-protein-coupled receptor, the apelin receptor APJ. Apelin is a peptide that was …
Apelin-13 protects against cisplatin-induced ototoxicity by inhibiting apoptosis and regulating STAT1 and STAT3
H Yin, Y Sun, B Ya, Y Guo, H Zhao, L Zhang… - Archives of …, 2023 - Springer
The ototoxic side effect of cisplatin is a main cause of sensorineural hearing loss. This side
effect limits the clinical application of cisplatin and affects patients' quality of life. This study …
effect limits the clinical application of cisplatin and affects patients' quality of life. This study …
Apelin-13: a protective role in vascular diseases
GG Zeng, SS Tang, WL Jiang, J Yu, GY Nie… - Current problems in …, 2024 - Elsevier
Vascular disease is a common problem with high mortality all over the world. Apelin-13, a
key subtype of apelin, takes part in many physiological and pathological responses via …
key subtype of apelin, takes part in many physiological and pathological responses via …
[HTML][HTML] Epigallocatechin gallate-loaded tetrahedral DNA nanostructures as a novel inner ear drug delivery system
The study of drug delivery systems to the inner ear is a crucial but challenging field. The
sensory organ (in the inner ear) is protected by the petrous bone labyrinth and the …
sensory organ (in the inner ear) is protected by the petrous bone labyrinth and the …
Apelin-13 attenuates injury following ischemic stroke by targeting matrix metalloproteinases (MMP), endothelin-B receptor, occludin/claudin-5 and oxidative stress
R Gholamzadeh, F Ramezani, PM Tehrani… - Journal of chemical …, 2021 - Elsevier
Oxidative stress, an adverse consequence of brain ischemia-reperfusion injury (IRI),
activates matrix metalloproteinase enzymes which cause to destruction of extracellular …
activates matrix metalloproteinase enzymes which cause to destruction of extracellular …
[HTML][HTML] Effect of noise and music on neurotransmitters in the amygdala: the role auditory stimuli play in emotion regulation
H Nian, S Ding, Y Feng, H Liu, J Li, X Li, R Zhang… - Metabolites, 2023 - mdpi.com
Stress caused by noise is becoming widespread globally. Noise may lead to deafness,
endocrine disorders, neurological diseases, and a decline in mental health. The mechanism …
endocrine disorders, neurological diseases, and a decline in mental health. The mechanism …
Exogenous apelin-13 administration ameliorates cyclophosphamide-induced oxidative stress, inflammation, and apoptosis in rat lungs
A Keskin-Aktan, Ö Kutlay - Protein and Peptide Letters, 2023 - ingentaconnect.com
Background: Apelin-13 is an endogenous adipocytokine known for its antioxidant,
antiinflammatory, and antiapoptotic properties. Objective: We aimed to investigate the …
antiinflammatory, and antiapoptotic properties. Objective: We aimed to investigate the …
[HTML][HTML] Diabetes mellitus, hearing loss, and therapeutic interventions: A systematic review of insights from preclinical animal models
R Mittal, G Keith, M Lacey, JRN Lemos, J Mittal… - Plos one, 2024 - journals.plos.org
Objectives The aim of this systematic review article is to evaluate the relationship between
diabetes mellitus (DM) and sensorineural hearing loss (SNHL) utilizing preclinical animal …
diabetes mellitus (DM) and sensorineural hearing loss (SNHL) utilizing preclinical animal …
Apelin‑13 reduces high glucose‑induced mitochondrial dysfunction in cochlear hair cells by inhibiting endoplasmic reticulum stress
Z Huo, J Gu, T He - Experimental and Therapeutic …, 2024 - spandidos-publications.com
The complex manifestation of diabetic hearing loss and the relative inaccessibility of the
inner ear contribute to the lack of research. The present study aimed to reveal the role of …
inner ear contribute to the lack of research. The present study aimed to reveal the role of …