The 3′ end of most protein-coding genes and long non-coding RNAs is cleaved and
polyadenylated. Recent discoveries have revealed that a large proportion of these genes …

The emerging awareness of the contribution of epigenetic processes to genome function in
health and disease is underpinned by decades of research in model systems. In particular …

DNA methylation is a fundamentally important epigenetic modification of the mammalian
genome that has widespread influences on gene expression. During germ-cell specification …

Gene copies that stem from the mRNAs of parental source genes have long been viewed as
evolutionary dead-ends with little biological relevance. Here we review a range of recent …

Imprinted genes play crucial roles in mammalian development and disruption of their
expression is associated with many human disorders including tumourigenesis; yet, the …

Genomic imprinting requires the differential marking by DNA methylation of genes in male
and female gametes. In the female germline, acquisition of methylation imprint marks …

Fundamental to genomic imprinting in mammals is the acquisition of epigenetic marks that
differ in male and female gametes at 'imprinting control regions'(ICRs). These marks mediate …

Non-coding RNAs (ncRNAs) that regulate gene expression in cis or in trans are a shared
feature of prokaryotic and eukaryotic genomes. In mammals, cis-acting functions are …

Genomic imprinting is widespread in eutherian mammals. Marsupial mammals also have
genomic imprinting, but in fewer loci. It has long been thought that genomic imprinting is …

Comparisons between eutherians and marsupials suggest limited conservation of the
molecular mechanisms that control genomic imprinting in mammals. We have studied the …