Mechanisms of vascular smooth muscle contraction and the basis for pharmacologic treatment of smooth muscle disorders
FV Brozovich, CJ Nicholson, CV Degen, YZ Gao… - Pharmacological …, 2016 - ASPET
The smooth muscle cell directly drives the contraction of the vascular wall and hence
regulates the size of the blood vessel lumen. We review here the current understanding of …
regulates the size of the blood vessel lumen. We review here the current understanding of …
Physiological functions of CRAC channels
SM Emrich, RE Yoast, M Trebak - Annual Review of Physiology, 2022 - annualreviews.org
Store-operated Ca2+ entry (SOCE) is a ubiquitous Ca2+ signaling pathway that is
evolutionarily conserved across eukaryotes. SOCE is triggered physiologically when the …
evolutionarily conserved across eukaryotes. SOCE is triggered physiologically when the …
STIM proteins: dynamic calcium signal transducers
Stromal interaction molecule (STIM) proteins function in cells as dynamic coordinators of
cellular calcium (Ca2+) signals. Spanning the endoplasmic reticulum (ER) membrane, they …
cellular calcium (Ca2+) signals. Spanning the endoplasmic reticulum (ER) membrane, they …
[HTML][HTML] Altered calcium signaling in cancer cells
TA Stewart, KTDS Yapa, GR Monteith - Biochimica et Biophysica Acta (BBA …, 2015 - Elsevier
It is the nature of the calcium signal, as determined by the coordinated activity of a suite of
calcium channels, pumps, exchangers and binding proteins that ultimately guides a cell's …
calcium channels, pumps, exchangers and binding proteins that ultimately guides a cell's …
Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of Alzheimer disease
B Oulès, D Del Prete, B Greco, X Zhang… - Journal of …, 2012 - Soc Neuroscience
In Alzheimer disease (AD), the perturbation of the endoplasmic reticulum (ER) calcium
(Ca2+) homeostasis has been linked to presenilins, the catalytic core in γ-secretase …
(Ca2+) homeostasis has been linked to presenilins, the catalytic core in γ-secretase …
STIM1 and Orai1 mediate CRAC channel activity and are essential for human glioblastoma invasion
RK Motiani, MC Hyzinski-García, X Zhang… - … -European Journal of …, 2013 - Springer
The Ca 2+ sensor stromal interacting molecule 1 (STIM1) and the Ca 2+ channel Orai1
mediate the ubiquitous store-operated Ca 2+ entry (SOCE) pathway activated by depletion …
mediate the ubiquitous store-operated Ca 2+ entry (SOCE) pathway activated by depletion …
[HTML][HTML] Orai3 is an estrogen receptor α-regulated Ca2+ channel that promotes tumorigenesis
RK Motiani, X Zhang, KE Harmon, RS Keller… - The FASEB …, 2013 - ncbi.nlm.nih.gov
Abstract Store-operated Ca 2+ entry (SOCE) encoded by Orai1 proteins is a ubiquitous Ca
2+-selective conductance involved in cellular proliferation and migration. We recently …
2+-selective conductance involved in cellular proliferation and migration. We recently …
[HTML][HTML] A coiled-coil clamp controls both conformation and clustering of stromal interaction molecule 1 (STIM1)
Store-operated Ca 2+ entry, essential for the adaptive immunity, is initiated by the
endoplasmic reticulum (ER) Ca 2+ sensor STIM1. Ca 2+ entry occurs through the plasma …
endoplasmic reticulum (ER) Ca 2+ sensor STIM1. Ca 2+ entry occurs through the plasma …
[HTML][HTML] STIM1-dependent peripheral coupling governs the contractility of vascular smooth muscle cells
Peripheral coupling between the sarcoplasmic reticulum (SR) and plasma membrane (PM)
forms signaling complexes that regulate the membrane potential and contractility of vascular …
forms signaling complexes that regulate the membrane potential and contractility of vascular …
Calcium channels in vascular smooth muscle
Abstract Calcium (Ca 2+) plays a central role in excitation, contraction, transcription, and
proliferation of vascular smooth muscle cells (VSMs). Precise regulation of intracellular Ca …
proliferation of vascular smooth muscle cells (VSMs). Precise regulation of intracellular Ca …