Ferroptosis is a type of cell death that was described less than a decade ago. It is caused by
the excess of free intracellular iron that leads to lipid (hydro) peroxidation. Iron is essential …

Hypothyroidism (HPT) HPT could be a risk factor for the development and progression of
Alzheimer's disease (AD). In addition, progressive neurodegeneration in AD may affect the …

Since its inception in the early 80s, inductively coupled plasma–mass spectrometry has
developed to the method of choice for the analysis of elements in complex biological …

Mitochondria are vital for energy production and redox homeostasis, yet knowledge of
relevant mechanisms remains limited. Here, through a genome-wide CRISPR-Cas9 …

Background: Abnormally hyperphosphorylated tau is a defining pathological feature of
tauopathies, such as Alzheimer's disease (AD), and accumulating evidence suggests a role …

Alzheimer's disease is pathologically characterized by abnormal accumulation of amyloid-
beta plaques, neurofibrillary tangles, oxidative stress, neuroinflammation, and …

Background Metals are pervasive throughout biological processes, where they play
essential structural and catalytic roles. Metals can also exhibit deleterious effects on human …

The dysregulation of metal homeostasis is reported to enhance the aggregation of tau, a key
neuronal microtubule-associated protein. Herein, we found that ferric (Fe3+) ions enhanced …

New analytical strategies for metal-binding protein facilitate researchers learning about how
metals play a significant role in life. Laser ablation–inductively coupled plasma mass …

Neuroimmune and neurodegenerative ailments impose a substantial societal burden.
Neuroimmune disorders involve the intricate regulatory interactions between the immune …