Tetanus and botulinum neurotoxins cause the neuroparalytic syndromes of tetanus and
botulism, respectively, by delivering inside different types of neurons, metalloproteases …

Tetanus and botulinum neurotoxins are the most poisonous substances known, so much so
as to be considered for a possible terrorist use. At the same time, botulinum neurotoxin type …

Sepsis is a life-threatening condition characterized by an uncontrolled inflammatory
response to an infectious agent and its antigens. Immune cell activation against the antigens …

Neurotoxins generally inhibit or promote the release of neurotransmitters or bind to
receptors that are located in the pre-or post-synaptic membranes, thereby affecting …

Erectile dysfunction (ED) is the inability to get and maintain an adequate penile erection for
satisfactory sexual intercourse. Due to its negative impacts on men's life quality and increase …

The unique nerve terminal targeting of botulinum neurotoxin type A (BoNT/A) is due to its
capacity to bind two receptors on the neuronal plasma membrane: polysialoganglioside …

Abstract Botulinum neurotoxin E (BoNT/E) is one of the major causes of human botulism and
paradoxically also a promising therapeutic agent. Here we determined the co-crystal …

Antioxidants are molecules characterized by function rather than common structural motifs.
Their common feature is the capability of acting “anti”-oxidants in biological systems. Owing …

Tetanus is a deadly but preventable disease caused by a protein neurotoxin produced by
Clostridium tetani. Spores of C. tetani may contaminate a necrotic wound and germinate into …

Botulinum neurotoxins (BoNTs) are a growing family of bacterial protein toxins that cause
botulism, a rare but often fatal animal and human disease. They are the most potent toxins …