Valproic acid (VPA) is an anti-seizure drug that causes idiosyncratic liver injury. 2-propyl-4-
pentenoic acid (Δ 4 VPA), a metabolite of VPA, has been implicated in VPA-induced …

Hepatic encephalopathy (HE) is a serious clinical complication, which could lead to coma
and death if not appropriately managed. There is agreement on the predominant role of …

It has been well documented that cirrhosis is associated with the intestinal injury. Intestinal
injury in cirrhosis could lead to bacterial lipopolysaccharide (LPS) translocation to the …

Valproic acid (VPA) is known as a common drug in seizure and bipolar disorders treatment.
Hepatotoxicity is the most important complication of VPA. Taurine (Tau), an amino acid, has …

Valproic acid (VPA) is a commonly used drug for management of epilepsy. Prolonged VPA
administration increases the risk of hepatotoxicity. Liraglutide is a glucagon‐like peptide 1 …

Cholestasis is not only influences the hepatic function but also damages many other organs.
Lung injury is a critical secondary organ damage associated with cholestasis/cirrhosis …

Лекарственно-ассоциированная жировая болезнь печени (ЛЖБП) это группа
осложнений фармакотерапии, распространенность которых составляет около 10% от …

Cholestasis/cirrhosis is a multifaceted clinical complication that influences many organs,
including the liver, kidney, heart, skeletal muscle, and lung. Cirrhosis-associated lung injury …

Cirrhosis-associated muscle mass loss or sarcopenia is a common complication (17-30%
prevalence) in cirrhotic patients. However, the pathogenesis of this complication is poorly …

Valproic acid (VPA) is one of the most broadly used drugs for epilepsy disorders worldwide.
Despite its great effectiveness, this drug causes liver toxicity. In this work, the effects of gallic …