Mechanical considerations for polymeric heart valve development: Biomechanics, materials, design and manufacturing

RL Li, J Russ, C Paschalides, G Ferrari, H Waisman… - Biomaterials, 2019 - Elsevier
The native human heart valve leaflet contains a layered microstructure comprising a
hierarchical arrangement of collagen, elastin, proteoglycans and various cell types. Here …

Clinical impact of computational heart valve models

M Toma, S Singh-Gryzbon, E Frankini, Z Wei… - Materials, 2022 - mdpi.com
This paper provides a review of engineering applications and computational methods used
to analyze the dynamics of heart valve closures in healthy and diseased states …

Biologically inspired scaffolds for heart valve tissue engineering via melt electrowriting

NT Saidy, F Wolf, O Bas, H Keijdener, DW Hutmacher… - Small, 2019 - Wiley Online Library
Heart valves are characterized to be highly flexible yet tough, and exhibit complex
deformation characteristics such as nonlinearity, anisotropy, and viscoelasticity, which are …

Deep autoencoders for physics-constrained data-driven nonlinear materials modeling

X He, Q He, JS Chen - Computer Methods in Applied Mechanics and …, 2021 - Elsevier
Physics-constrained data-driven computing is an emerging computational paradigm that
allows simulation of complex materials directly based on material database and bypass the …

Manifold learning based data-driven modeling for soft biological tissues

Q He, DW Laurence, CH Lee, JS Chen - Journal of biomechanics, 2021 - Elsevier
Data-driven modeling directly utilizes experimental data with machine learning techniques
to predict a material's response without the necessity of using phenomenological constitutive …

A detailed mechanical and microstructural analysis of ovine tricuspid valve leaflets

WD Meador, M Mathur, GP Sugerman, T Jazwiec… - Acta biomaterialia, 2020 - Elsevier
The tricuspid valve ensures unidirectional blood flow from the right atrium to the right
ventricle. The three tricuspid leaflets operate within a dynamic stress environment of shear …

Parameterization, geometric modeling, and isogeometric analysis of tricuspid valves

EL Johnson, DW Laurence, F Xu, CE Crisp… - Computer methods in …, 2021 - Elsevier
Approximately 1.6 million patients in the United States are affected by tricuspid valve
regurgitation, which occurs when the tricuspid valve does not close properly to prevent …

A physics-guided neural operator learning approach to model biological tissues from digital image correlation measurements

H You, Q Zhang, CJ Ross… - Journal of …, 2022 - asmedigitalcollection.asme.org
We present a data-driven workflow to biological tissue modeling, which aims to predict the
displacement field based on digital image correlation (DIC) measurements under unseen …

An investigation of regional variations in the biaxial mechanical properties and stress relaxation behaviors of porcine atrioventricular heart valve leaflets

D Laurence, C Ross, S Jett, C Johns, A Echols… - Journal of …, 2019 - Elsevier
The facilitation of proper blood flow through the heart depends on proper function of heart
valve components, and alterations to any component can lead to heart disease or failure …

Mechanics of the tricuspid valve—From clinical diagnosis/treatment, in-vivo and in-vitro investigations, to patient-specific biomechanical modeling

CH Lee, DW Laurence, CJ Ross, KE Kramer, AR Babu… - Bioengineering, 2019 - mdpi.com
Proper tricuspid valve (TV) function is essential to unidirectional blood flow through the right
side of the heart. Alterations to the tricuspid valvular components, such as the TV annulus …