Transcription start site (TSS) selection influences transcript stability and translation as well
as protein sequence. Alternative TSS usage is pervasive in organismal development, is a …

RNA polymerase (RNAP) II frequently transcribes non-protein-coding DNA sequences in
eukaryotic genomes into long noncoding RNA (lncRNA). Distinct molecular mechanisms …

We recently described an unconventional mode of gene regulation in budding yeast by
which transcriptional and translational interference collaborate to down-regulate protein …

Gametogenesis requires packaging of the cellular components needed for the next
generation. In budding yeast, this process includes degradation of many mitotically stable …

The mitosis to meiosis transition requires dynamic changes in gene expression, but whether
and how the mitotic transcriptional machinery is regulated during this transition is unknown …

Alternative transcription start sites can affect transcript isoform diversity and translation
levels. In a recently described form of gene regulation, coordinated transcriptional and …

In many cell types, disparate non-centrosomal microtubule-organizing centers (ncMTOCs)
replace functional centrosomes and serve the unique needs of the cell types in which they …

Gametogenesis requires packaging of the cellular components needed for the next
generation. In budding yeast, this process includes degradation of many mitotically stable …

Precision genome-editing approaches have long been available in budding yeast, enabling
introduction of gene deletions, epitope tag fusions, and promoter swaps through a selection …

Transcription factors induce dynamic changes in gene expression to drive cellular
differentiation. During the mitotic G1/S of budding yeast when the cell irreversibly commits to …